Publications by authors named "S P Toth"
Drug resistance is a major obstacle in cancer treatment. Herein, four novel organometallic complexes, with the general formula [Ru(η--cymene)(HL)Cl]Cl and [Rh(η-CMe)(HL)Cl]Cl, were developed to target multidrug-resistant (MDR) cancer cells, where HL denotes 8-hydroxyquinoline-derived Mannich bases (HQCl-pyr and HQCl-pip). The aim of the complexation was to obtain compounds with improved drug-like properties.
View Article and Find Full Text PDFArticle Synopsis
- The study examined how E. coli infection affects cell turnover and cell death (apoptosis) in the intestines of germ-free piglets.
- Researchers compared healthy germ-free piglets to those colonized with E. coli, finding an increase in epithelial cell proliferation in the jejunum of the infected group.
- Significant changes in markers related to inflammation and apoptosis were observed in the lamina propria of both intestinal areas, indicating that gut bacteria influence cell behavior and the body's response to infection.
Mitochondria form a dynamic network in cells, regulated by the balance between mitochondrial fusion and fission. The inhibition of mitochondrial fission can have positive effects in acute ischemic/reperfusion injury models by preventing the fall in mitochondrial membrane potential associated with fission processes. However, inhibition of fission in chronic models is disadvantageous because it obstructs the elimination of damaged mitochondrial fragments.
View Article and Find Full Text PDFLaser-driven deuterons generate neutrons with a mean energy of 2.5 MeV, through the H(d,n) fusion reaction in a deuterated polyethylene (dPE) tablet. The deuterium ions are accelerated by 12 fs, 21 mJ laser pulses interacting with a 0.
View Article and Find Full Text PDFObjectives: To explore associations between periodontal disease (PD) severity and cardiometabolic risk factors, including body mass index (BMI), age, Type 2 Diabetes Mellitus (T2DM) risk, sex, and hypertension (HTN) in patients at an urban dental school clinic.
Methods And Materials: A cross-sectional study design was used to analyze electronic health record data, including periodontal status, demographic characteristics, cardiometabolic risk factors and the American Diabetes Association Diabetes Risk Test (DRT) Score. Chi-square tests and ordinal logistic regression were conducted using SAS 9.