Publications by authors named "S P Thacker"
The 18 Workshop on Recent Issues in Bioanalysis (18 WRIB) took place in San Antonio, TX, USA on May 6-10, 2024. Over 1100 professionals representing pharma/biotech companies, CROs, and multiple regulatory agencies convened to actively discuss the most current topics of interest in bioanalysis. The 18 WRIB included 3 Main Workshops and 7 Specialized Workshops that together spanned 1 week to allow an exhaustive and thorough coverage of all major issues in bioanalysis of biomarkers, immunogenicity, gene therapy, cell therapy and vaccines.
View Article and Find Full Text PDFCharacterizing and mitigating factors that impact product immunogenicity can aid in risk assessment and/or managing risk following manufacturing changes. For follow-on products that have the same indication, patient population, and active product ingredient, the residual immunogenicity risk resides predominantly on differences in product and process related impurities. Characterizing differences in innate immune modulating impurities (IIRMI), which could act as adjuvants by activating local antigen presenting cells (APCs), can inform the immunogenicity risk assessment potentially reducing the need for clinical trials.
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- * Researchers examined 172 cases and found that 58% had a positive urine culture, with most infections caused by Escherichia coli, yet only 17% of the prescribed antibiotic regimens were appropriate.
- * The results highlighted widespread inappropriate use of broad-spectrum antibiotics, particularly third cephalosporins, and indicated a need for better treatment protocols to avoid unnecessary prescriptions and prolonged treatments.
Article Synopsis
- - The study investigates the effects of an herbal treatment on gut microbiome, facial redness, and intestinal permeability in adults diagnosed with small intestinal bacterial overgrowth (SIBO) confirmed by a lactulose breath test.
- - Participants underwent a 10-week regimen of a Biocidin liquid tincture and GI Detox+, with additional treatment via Olivirex if they showed no improvement, monitored through breath tests and other analyses.
- - Results indicated that the herbal regimen was particularly effective for certain types of SIBO, with 42.8% of participants showing improvement in hydrogen-dominant cases and significant increases in beneficial bacteria over the treatment period.
Introduction: Daptomycin (DAP) is a cyclic lipopeptide that exhibits potent in vitro activity against many drug-resistant gram-positive organisms, including methicillin-resistant (MRSA) and vancomycin-resistant enterococci (VRE). Despite substantial reports evaluating the clinical outcomes of DAP within the adult population, real-world data are lacking in children. The primary goal of this evaluation was to describe the clinical characteristics and outcomes of DAP use in pediatric patients across a wide range of infections.
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