Interaction between tumor stage and age on survival outcomes of patients with anaplastic thyroid cancer.

Background: Anaplastic thyroid cancer (ATC) is an aggressive, rare malignancy associated with rapid growth and metastasis, and a very poor prognosis. We investigated the clinical characteristics, survival outcomes and independent prognostic factors associated with anaplastic thyroid cancer.

Aim: To assess to what extent the interaction between age and tumor stage affects mortality.

Global geoepidemiology of gastrointestinal surgery rates in Crohn's disease.

Background: Data regarding the worldwide gastrointestinal surgery rates in patients with Crohn's disease (CD) remains limited.

Aim: To systematically review the global variation in the rates of surgery in CD.

Methods: A comprehensive search analysis was performed using multiple electronic databases from inception through July 1, 2020, to identify all full text, randomized controlled trials and cohort studies pertaining to gastrointestinal surgery rates in adult patients with CD.

High Frequency of Tumor Propagating Cells in Fusion-Positive Rhabdomyosarcoma.

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Fusion-positive RMS (FPRMS), expressing the PAX3/7-FOXO1, has a worse prognosis compared to the more common fusion-negative RMS (FNRMS). Although several studies reported hierarchical organization for FNRMS with the identification of cancer stem cells, the cellular organization of FPRMS is not yet clear.

Acute hepatozoonosis in dogs: a case report.

Two male dogs aged between 2 and 3 months belonging to German Shepherd and non descript breed were brought to Outpatient unit of Department of Veterinary Medicine, Veterinary College, Bidar with history of anorexia, weakness and going down in body condition since 15 days. Clinical examination revealed fever, enlargement of popliteal and submandibular lymph nodes, pale mucous membranes and cachectic body condition in both the cases. Haemato-biochemical examination revealed anemia, leukocytosis, thrombocytopenia, hypoalbuminemia and elevated levels of blood urea nitrogen, creatinine and alanine amino transferase.

Targeting hedgehog signaling reduces self-renewal in embryonal rhabdomyosarcoma.

Current treatment regimens for rhabdomyosarcoma (RMS), the most common pediatric soft tissue cancer, rely on conventional chemotherapy, and although they show clinical benefit, there is a significant risk of adverse side effects and secondary tumors later in life. Therefore, identifying and targeting sub-populations with higher tumorigenic potential and self-renewing capacity would offer improved patient management strategies. Hedgehog signaling has been linked to the development of embryonal RMS (ERMS) through mouse genetics and rare human syndromes.