Single (375 mg/m) vs. double dose of rituximab along with mycophenolate mofetil for children with steroid-dependent/frequently relapsing nephrotic syndrome: a multicentre open-label randomized controlled trial.

Background: Optimal dosing of rituximab when given with mycophenolate mofetil (MMF) for frequently relapsing nephrotic syndrome/steroid-dependent nephrotic syndrome (FRNS/SDNS) remains uncertain.

Methods: This was a prospective, non-inferiority, open-label randomized controlled multicentre study. Children (2-18 years old) with difficult FRNS/SDNS were randomized to group A (rituximab 375 mg/m once) or group B (rituximab 375 mg/m twice; 7-14 days apart) followed by continuous MMF and 3 months of tapered steroids.

MOF-Derived Hollow C, N-Doped CoO Dodecahedral Nanostructure Enwrapped with MgInS Nanosheets for Enhanced Photocatalytic N Reduction.

Design of hierarchical hollow nanoheterostructure materials through interfacial and defect engineering is an innovative approach for achieving optimal charge separation dynamics and photon harvesting efficiency. Herein, we have described a facile technique to fabricate hollow MOF-derived C, N-doped-CoO (C, N-CoO) dodecahedral particles enwrapped with MgInS nanosheets for enhanced N reduction performance. ZIF-67 was initially used as a sacrificial template to prepare hollow C, N-CoO using a carbonization route followed by low-temperature calcination treatment.

Seroprevalence of Measles Antibodies Among Migrant Populations: A Systematic Review and Meta-Analysis.

Incomplete or interrupted vaccination schedules put migrant communities at higher risk for measles, which remains a serious public health concern. The objective of this systematic review was to evaluate the pooled seroprevalence of measles antibodies among migrant groups globally and offer data to guide public health initiatives. Our literature search included PubMed, Scopus, and Embase databases, covering publications from 1990 to 2023, and was systematically refined using specific inclusion and exclusion criteria.

Methaemoglobinaemia in neonates with acute gastroenteritis: lethal, but curable.

Methaemoglobinaemia is a rare factor that can lead to cyanosis. The predominant cause of acquired methaemoglobinaemia is commonly attributed to anaesthetic agents. This case series presents three instances of acquired methaemoglobinaemia resulting from acute gastroenteritis caused by formula feeds.

Photocatalytic regioselective C-H bond functionalizations in arenes.

The direct functionalization of C-H bonds has revolutionized the field of synthetic organic chemistry by enabling efficient and atom-economical modification of arenes by avoiding prefunctionalization. However, the inherent challenges of inertness and regioselectivity in different C-H bonds, particularly for distal positions, necessitate innovative approaches. In this aspect, photoredox catalysis by utilizing both transition metal and organic photocatalysts has emerged as a powerful tool for addressing these challenges under mild reaction conditions.