[Changes in oxygen tension in tumor during induced hyperglycemia].

It is shown that tumour PO2 falls by the factor of 2 or 3 at the 120-150 min i/v glucose infusion (80 mg.kg-1.min-1) to the rats bearing Guerin carcinoma.

[Methods for creating hyperthermia in tumors by using electromagnetic fields].

Evidence on the methods for creation of hyperthermia in treatment of human tumours using superhigh-frequency external, intracavitary, and implanted irradiators are generalized. Inductive, capacitive and interstitial methods of heating are described. Advantages and shortcomings, depths of heating and heat-production structures are presented for each method.

[Interstitial hyperthermia method in spontaneous tumors].

To induce hyperthermia of spontaneous tumors in dogs an interstitial method of heating was used: electrodes in the form of injection needles were implanted around tumors. Necessary temperature levels could not be attained in a dog with circumanal angiosarcoma because the tumor was well vascularized and had a considerable volume. No thermal damage of the animals' skin was observed during all sessions of hyperthermia.

[The microenvironment of tumor cells and the antitumor effect of hyperthermia].

Intravenous infusion of 20% solution of glucose (80 mg/kg of body mass per 1 min) resulted in considerable changes in microenvironment of tumor cells: by the 90th-120th min of infusion there was a decrease in pH, pO2, blood flow inhibition, an increase in the relative number of cells in the S-phase of the mitotic cycle in a tumor. There was no increase in tumor ATP and glucose up to the values at which these substance could enhance thermoresistance, a situation being rather favorable for realizing a damaging effect of hyperthermia. The use of hyperglycemia in the above regimen prior to MWF-hyperthermia enhanced 2-3 times its antitumor effect on the model of subcutaneously transplanted Guéren carcinoma and Pliss lymphosarcoma.