Publications by authors named "S P Muthukumar"

Patients with cirrhosis have high systemic inflammation (TNFα, CRP, and IL-6) that is associated with poor outcomes. These biomarkers need continuous non-invasive monitoring, which is difficult with blood. We studied the AWARE sweat-sensor to measure these in passively expressed sweat in healthy people (N = 12) and cirrhosis (N = 32, 10 outpatients/22 inpatients) for 3 days.

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This research aims to develop a portable biosensor device for quickly detecting vWFA2, a biomarker for inflammatory conditions. This sensor could dramatically change detection methods and lead us to improve the sensitivity of our tests to overcome the limitations of conventional detection methods. Our label-free biomolecular assay is constructed on an Au-ZnO electrode surface and uses electrochemical impedance spectroscopy (EIS) to measure the capacitive change in impedance, revealing the binding effects of the target vWFA2, to the capture probe.

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Article Synopsis
  • * Traditional limitations in analyzing dynamic biorhythmic processes are addressed through advanced biosensors, enabling continuous, non-invasive monitoring of key biomarkers related to stress, sleep, metabolism, and immune responses.
  • * The use of nanobiosensing technology can lead to personalized treatment options in psychiatry, enhancing disease management, early relapse prediction, and overall patient outcomes by focusing on the underlying pathophysiology rather than just symptoms.
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The world is facing a food shortage predicament largely fueled by inefficient, outdated farming conventions that are passed down from generation to generation. Overfertilization is one of the major byproducts of inadequate farming techniques. This leads to an imbalance in the soil ecosystem, affecting carbon sequestration, plant-available nutrients, and microorganisms.

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