[Computed analysis of brain electrograms under the action of psychotropic drugs].

The computed analysis of the EEG-effects of a neuroleptic ethaperazine and an antidepressant melipramine administered in different doses was made in the experiments on cats. It was established that ethaperazine (3 mg/kg) and melipramine (6 mg/kg) increase the spectral power in the range of 1-2 Hz; the maximal effect was noted 2 hours after their oral administration Ethaperazine primarily decreases the powers of the spectra of the hypothalamus and reticulotegmental nucleus in the range of 13-14 Hz and over. Melipramine in a dose of 6 mg/kg decreases the spectral power of the hippocampus in the range of 4-12 Hz, of the mediodosal and caudal nuclei in the range of 8-12 Hz.

[Electrophysiologic analysis of the function of various limbic system structures in experimental traumatic shock].

The thresholds of convulsive reaction and duration of epi-discharges in the dorsal hippocamp and basolateral amygdala exposed to high-frequency electrical stimulation were studied in experiments on cats with traumatic shock. The thresholds of convulsive reaction were found to be significantly increased and the duration of epi-discharges shortened. This indicates marked depression of the function of the structures under study in the course of the shock development.

[Functional state of the cerebral cortex and midbrain reticular formation during traumatic shock].

Acute experiments on cats were carried out during traumatic shock to study evoked potentials in the sensorimotor cortex and reticular formation (RF) of the midbrain in response to electrodermal irritation of the contralateral paw. The cortical function was judged by thresholds of convulsant reaction while function of RF by thresholds of activation reaction in the cortex of the course of high-frequency electrical stimulation of the structures under study. It was shown that in traumatic shock, initial and pronounced depression of the cortical function paralleled long enough stability of RF functional activity.