Transitioning From Nusinersen to Risdiplam for Spinal Muscular Atrophy in Clinical Practice: A Single-Center Experience.

Background: Nusinersen and risdiplam are U.S. Food and Drug Administration (FDA)-approved treatments for spinal muscular atrophy (SMA).

Irregularly regulated collecting markets: antiquities, fossils, and wildlife.

This paper examines the dynamics of 'irregularly regulated markets', specifically those dealing with what we term 'criminogenic collectables': antiquities, fossils, and wildlife. Through the lens of 'irregular regulation' we consider how inconsistencies and loopholes in legal frameworks contribute to criminal activities in these markets. We outline five ways that such markets can be considered irregular: socially, jurisdictionally, temporally, culturally and discursively.

Short-Term High Light Stress Analysis Through Differential Methylation Identifies Root Architecture and Cell Size Responses.

DNA methylation repatterning is an epigenomic component of plant stress response, but the extent that methylome data can elucidate changes in plant growth following stress onset is not known. We applied high-resolution DNA methylation analysis to decode plant responses to short- and long-term high light stress and, integrating with gene expression data, attempted to predict components of plant growth response. We identified 105 differentially methylated genes (DMGs) following 1 h of high light treatment and 193 DMGs following 1 week of intermittent high light treatment.

Clinical predictors of treatment response to gabapentin in women with unexplained chronic pelvic pain.

Introduction: Chronic pelvic pain affects up to 24% of women worldwide and for up to 55% of these there is no associated pathology. Despite this there are no established treatments in this cohort. This is a secondary analysis of a randomised-controlled trial (GaPP2) to explore if there are measures which enable us to predict treatment outcome.

Range-wide post- and pre-breeding migratory networks of a declining neotropical-nearctic migratory bird, the blackpoll warbler.

Identifying the drivers of population declines in migratory species requires an understanding of how individuals are distributed between periods of the annual cycle. We built post- (fall) and pre-breeding (spring) migratory networks for the blackpoll warbler (Setophaga striata), a Neotropical-Nearctic songbird, using tracking data from 47 light-level geolocators deployed at 11 sites across its breeding range. During pre-breeding migration, two stopover nodes (regions) on the U.