Publications by authors named "S P Kennelly"
Article Synopsis
- The study explores how a sensory support intervention (SSI) program impacts quality of life in individuals with mild-to-moderate dementia who also have hearing and vision difficulties.
- Researchers conducted a randomized controlled trial across seven clinics in five European countries, evaluating the effectiveness of an 18-week program compared to standard care.
- The primary outcome measured was changes in health-related quality of life, using the Dementia Quality of Life Instrument (DEMQoL), with a total of 252 participants randomly assigned to either the SSI group or a control group receiving usual care.
Article Synopsis
- The study aims to explore patient eligibility for lecanemab therapy for Alzheimer's Disease (AD) at a Regional Specialist Memory Clinic, emphasizing the importance of timely treatment in early AD cases.
- A retrospective analysis was conducted on 188 new patients over a year, assessing their diagnostic data and biomarker status to determine eligibility based on Appropriate Use Criteria (AUC) and clinical trial standards.
- Results showed only 5.9% of the patients were eligible according to AUC, with a higher eligibility rate of 26.2% among those with biomarker positive Alzheimer's, highlighting major barriers like lack of biomarker confirmation and cognitive ineligibility.
Use of biomarkers in the diagnosis of Alzheimer's disease in adults with intellectual disability.
Lancet Healthy Longev
October 2024
Article Synopsis
- People with intellectual disability have a higher risk of developing dementia, which often shows different and earlier symptoms than in the general population, complicating diagnosis.
- There is a need for specialized memory services and reliable biomarkers to improve diagnosis and treatment options for this group, but current research and services are lacking.
- The underrepresentation of adults with intellectual disabilities in biomarker research could lead to their exclusion from effective treatments for neurodegenerative diseases, worsening existing health care inequities.
Article Synopsis
- Midlife cardiovascular risk factors, like Type 2 Diabetes (T2DM) and obesity, may lead to cognitive impairment and dementia, with systemic inflammation being a potential link.
- A study assessed middle-aged individuals with and without uncomplicated T2DM, measuring their cognitive abilities and levels of certain inflammatory markers (like IL-17A) over four years.
- Results showed that higher levels of IL-17A were correlated with poorer executive function, regardless of T2DM status, suggesting this inflammatory marker may play a role in cognitive decline in midlife.
Background: The estimated prevalence of tracheobronchomalacia (TBM) in children is about 1:2100. Prevalence of intrathoracic malacia is higher in children with chronic lung disease such as bronchiectasis and cystic fibrosis (CF) and may contribute to increased morbidity.
Objective: To determine the prevalence and assess clinical features of tracheomalacia (TM), TBM and bronchomalacia (BM) in patients with primary ciliary dyskinesia (PCD).