[Pharmacokinetic characteristics of propranolol in patients with a history of acute myocardial infarct].

Peculiarities of propranolol pharmacokinetics in patients with acute myocardial infarction were determined after oral administration of 80 mg of the drug and compared with control group of patients with stage II hypertensive disease: a significant increase of Cmax, Tmax and AUC without changes of kel and T1/2. A direct linear correlation (r = 0.86, p = 0.

Derivatization of endogenous and exogenous compounds in plasma for high-performance liquid chromatographic analysis.

Methods are described for the analysis of endogenous (acetoacetic and pyruvic acids) and exogenous (propranolol) compounds in plasma. Acetoacetic and pyruvic acids were converted into 2,4-dinitrophenylhydrazones and identified by chromatography on a normal-phase silica gel column at 360 nm. The propranolol amino group was modified with dansyl chloride and the dansyl derivative, after extraction with a hydrophobic solvent, was analysed on a normal-phase silica gel column using fluorescence detection.

[Cimetidine pharmacokinetics].

The pharmacokinetics of cimetidine was studied in 9 patients at a single intravenous (200 mg) and oral (400 mg) administration. The pharmacokinetic parameters at intravenous administration were calculated according to a two-compartment model. The time-concentration curve after oral drug administration had two maxima between 45 min and 2 hrs with approximately equal concentrations of cimetidine.

[Proteolytic enzymes bound to Bac. thuringiensis crystals].

It was demonstrated that crystals of entomopathogenic protein from Bac. thuringiensis contain admixture of proteinase either adhered to their surface on inconponated into crystal lattice defects. A proteolytic action, particularly when enhanced by crystal dissolution, causes progressive degradation of crystal proteins with molecular weights of 140 000--129 000 down to the components with smaller molecular weights.