Publications by authors named "S P K Jagdev"
Article Synopsis
- Taxane-based chemotherapy, specifically paclitaxel, is commonly used for treating platinum- and immunotherapy refractory metastatic urothelial carcinoma (mUC), but survival outcomes are generally poor and biomarkers for predicting outcomes are lacking.
- A study was conducted using whole-transcriptome profiles from patients enrolled in a trial (PLUTO) to evaluate gene signatures related to survival, focusing on factors like immuno-oncology, angiogenesis, and genome instability.
- Results indicated that patients with high expressions of genome instability and evading growth suppressors experienced significantly better progression-free survival (PFS) and overall survival (OS), while activation of angiogenesis was associated with worse outcomes across both treatment cohorts.
JCO POUT was a phase III, randomized, open-label trial, including 261 patients with muscle-invasive or lymph node-positive, nonmetastatic upper tract urothelial cancer (UTUC) randomly assigned after radical nephroureterectomy to platinum-based chemotherapy (132) or surveillance (129). Primary outcome analysis demonstrated that chemotherapy improved disease-free survival (DFS). At that time, the planned secondary outcome analysis of overall survival (OS) was immature.
View Article and Find Full Text PDFThere is a lack of cheap and effective biomarkers for the prediction of renal cancer outcomes post-image-guided ablation. This is a retrospective study of patients with localised small renal cell cancer (T1a or T1b) undergoing cryoablation or radiofrequency ablation (RFA) at our institution from 2003 to 2016. A total of 203 patients were included in the analysis.
View Article and Find Full Text PDFObjective: To compare long-term outcomes and peri-operative outcomes of image-guided ablation (IGA) and laparoscopic partial nephrectomy (LPN).
Material And Methods: This is a retrospective cohort study of localised RCC (T1a/bN0M0) patients undergoing cryoablation (CRYO), radio-frequency ablation (RFA), or LPN at our institution from 2003 to 2016. Oncological outcomes were compared using Cox regression and log-rank analysis.
Objectives: To analyse the safety, technical feasibility, long-term renal function and oncological outcome of multimodal technologies in image-guided ablation (IGA) for renal cancer in Von-Hippel-Lindau (VHL) patients, and to evaluate factors that may influence the outcome.
Methods: Retrospective analysis of a prospective database of VHL patients who underwent IGA at a specialist centre. Patient's demographics, treatment energy, peri-operative outcome and oncological outcomes were recorded.