[Changes in lipid metabolism in rats with radiation sickness and a pronounced intestinal syndrome following local irradiation of the abdominal region. Fatty acid composition of the blood and tissue phospholipids].

Local irradiation of rat abdomen (13.5 Gy) caused similar changes in fatty-acid composition of phospholipids in the liver, thymus and brain, that is: (a) a decrease in the polyunsaturated fatty acid content in 4 h, (b) a hypercompensatory increase in the content of polyunsaturated fatty acids (excluding thymus) in 24 h, the ratio between essential fatty acids and their derivatives being changed towards accumulation of the latter, and (c) a trend toward normalization in 72 h.

[Changes in lipid metabolism in rats with radiation sickness and a pronounced intestinal syndrome during parenteral feeding with lipofundin and infusolipol].

Local X-irradiation of rat abdomen (13.5 Gy) caused a pronounced intestinal syndrome which was partially coped with by parenteral feeding. The results indicate (1) a satisfactory assimilation of fatty emulsions used at certain doses and with certain parenteral diet composition, (2) a favourable effect of fatty emulsions on lipid metabolism in irradiated rats, and (3) some advantages of the parenteral feeding with infusolipol over lipofundin S.

[Effect of glutathione on the course of radiation sickness with a marked gastrointestinal syndrome and the effectiveness of parenteral feeding in an experiment].

Injections of oxidized glutathione (40 mg/kg, 5-7 days) combined with the parenteral nutrition (PN) of rats after local X-irradiation of abdomen (13-14.5 Gy) increased significantly the survival rate, decreased the gastrointestinal syndrome manifestations, and intensified the assimilation of a PF amino acid component. The reduced glutathione had no effect.

[Effect of local x-ray irradiation of the abdominal area on the amino acid content of the blood plasma and their urinary excretion in dogs and rats].

A study was made of the content of amino acids in blood plasma of dogs and rats and daily excretion thereof from rat body in urine after local X-irradiation of abdomen with a dose of 13.5 Gy. As the gastrointestinal syndrome developed the content and excretion of taurine increased, glucogenic amino acid content of plasma decreased, and the ratio of phenylalanine to tyrosine and branched-chain amino acids to aromatic amino acids changed.

[Effect of ADP on the course of radiation sickness and various metabolic processes in rats after local irradiation of the abdomen and parenteral feeding].

The intraperitoneal administration of ADP (150-75 mg/kg/day) to rats on days 1-3 after exposure of abdomen to X-rays (13.5 Gy) enhanced the assimilation of glucose, amino acids and electrolyte introduced with the parenteral feeding and increased considerably the survival rate of animals.