Publications by authors named "S P Galant"

The small airways comprise generations 8 to 23 of the bronchial tree, consist of airways with an internal diameter <2mm, and are classically difficult to assess and treat in persistent asthma. Small airways dysfunction (SAD) is integral to the asthma management paradigm as it is associated with poorer symptom control, greater levels of type 2 inflammation, and has been proposed as a potential treatable asthma trait. Although identification of SAD by oscillometry has been found to be clinically useful in managing asthma, very few physicians, including specialists, use this technique as part of standard or adjunct evaluation of lung function to diagnose asthma, grade severity of airway obstruction, ascertain disease control or the risk for future exacerbations or to make management decisions.

View Article and Find Full Text PDF

Background: World Health Organization (WHO) tuberculosis (TB) screening guidelines recommend computer-aided detection (CAD) software for chest radiograph (CXR) interpretation. However, studies evaluating their diagnostic and prognostic accuracy are limited.

Methods: We conducted a prospective cohort study of household contacts of rifampicin-resistant TB in South Africa.

View Article and Find Full Text PDF

Background: A possible explanation for the continued risk of asthma exacerbations while utilizing current asthma guideline-based management is the failure to consider small airway dysfunction (SAD) and eosinophilic airway inflammation in assuming asthma-controlled status.

Objective: To construct a practical algorithm that potentially identifies additional risks of not well-controlled (NWC) asthma and exacerbations beyond guideline criteria with oscillometry and fractional exhaled nitric oxide (FENO) determination.

Methods: This was a retrospective, posthoc analysis of 183 children, ages 4-18 years, with moderate-to-severe asthma, characterized by demographic factors, National Health Lung and Blood Institute (NHLBI) determined asthma-controlled status, therapy step, and lung function status.

View Article and Find Full Text PDF

Introduction: Identifying the asthmatic early to prevent permanent airway remodeling and the progression of the disease is desirable. In children, baseline impulse oscillometry has been found effective in identifying asthma in some studies but not others.

Objective: The purpose of our study was to utilize a meta-analysis to determine whether there were significant peripheral airway differences between asthmatic and non-asthmatic children across ethnicity/race, utilizing baseline impulse oscillometry (IOS) to establish its usefulness as a diagnostic tool in this age group.

View Article and Find Full Text PDF