Publications by authors named "S P Fragoso"
DNA lesions that block transcription induce the death of Trypanosoma cruzi via ATR activation, which is dependent on the presence of R-loops.
DNA Repair (Amst)
September 2024
Article Synopsis
- Trypanosoma cruzi, the agent responsible for Chagas disease, exhibits unique biological traits and responds to DNA damage through a specific repair pathway called transcription-coupled nucleotide excision repair (TC-NER).
- When UV light induces DNA lesions, unresolved transcriptional stress can lead to a programmed cell death mechanism that resembles apoptosis.
- The study reveals that the Cockayne Syndrome B protein (CSB) plays a crucial role in this process, as its overexpression increases cell death after UV exposure, while its absence confers resistance, suggesting an ATR-dependent apoptosis-like signaling in T. cruzi.
Avian reovirus (ARV) is associated with arthritis/tenosynovitis and malabsorption syndrome in chickens. The σC and σB proteins, both exposed to the virus capsid, are highly immunogenic and could form the basis for diagnostic devices designed to assess the immunological status of the flock. Commercial ARV ELISAs cannot distinguish between vaccinated and infected animals and might not detect circulating ARV strains.
View Article and Find Full Text PDFSesbania virgata (Cav.) Pers. seeds are protein sources with health and environmental benefits.
View Article and Find Full Text PDFBackground: Conventional microscopic counting is a widely utilised method for evaluating the trypanocidal effects of drugs on intracellular amastigotes. This is a low-cost approach, but it is time-consuming and reliant on the expertise of the microscopist. So, there is a pressing need for developing technologies to enhance the efficiency of low-cost anti-Trypanosoma cruzi drug screening.
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