Publications by authors named "S P Doyle"

Objective: Artificial intelligence (AI) chatbots, including chat generative pretrained transformer (ChatGPT) and Google Gemini, have significantly increased access to medical information. However, in pediatric orthopaedics, no study has evaluated the accuracy of AI chatbots compared with evidence-based recommendations, including the American Academy of Orthopaedic Surgeons clinical practice guidelines (AAOS CPGs). The aims of this study were to compare responses by ChatGPT-4.

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Article Synopsis
  • This case report discusses a pediatric patient with focal fibrocartilaginous dysplasia (FFCD) who experienced angular deformity and growth arrest, even with standard guided growth management.
  • The patient initially underwent implant-mediated guided growth for correcting a proximal tibia varus deformity, but the issue recurred, leading to the identification of a physeal bar that resulted in complete physeal arrest.
  • The report concludes that while treatment for FFCD-related angular deformity may involve observation and guided growth, there is a significant risk of complete physeal arrest that needs to be considered.
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Background: Cancer patients are known to be associated with increased risk of cardiovascular disease. However, no studies have examined the differential impact of hematologic malignancies (HMs) and solid tumors (STs) on cardiac morphology at the tissue level.

Objective: We aimed to examine histopathological features alongside cardiovascular biomarkers in patients with HMs and STs who underwent post-mortem evaluation.

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Reconciling organism-scale biology at cellular-scale resolution has been a monumental challenge. Recently, Gramberg et al. uncovered the spatial organisation of gene expression in the common liver fluke, Fasciola hepatica.

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Article Synopsis
  • People experiencing homelessness often face poor mental health, addiction issues, and non-communicable diseases, highlighting the need for effective rehabilitation and nutritional support.
  • This study aims to assess the feasibility and impact of a 12-week low-threshold physical rehabilitation program that includes protein supplementation for individuals with substance use problems who are homeless.
  • The research will track participant engagement, physical outcomes, and any side effects, with hopes of generating data to support a larger trial in the future.
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