Publications by authors named "S P Cowley"

In recent decades there has been significant interest among policy makers in supporting entrepreneurship among university students, with the goal to improve labor market outcomes and contribute to the economy through venture creation. Drawing from the 2018 National Graduate Survey in Canada, our study examines who engages in entrepreneurial activity after graduation, investigating differences among demographic groups and between those who participated in entrepreneurship education on campus and those who did not participate. We find that those graduates who participated in entrepreneurship education are more likely to be self-employed and own their own business three years after graduating than the general population of university graduates.

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For the protozoan parasite Leishmania, completion of its life cycle requires sequential adaptation of cellular physiology and nutrient scavenging mechanisms to the different environments of a sand fly alimentary tract and the acidic mammalian host cell phagolysosome. Transmembrane transporters are the gatekeepers of intracellular environments, controlling the flux of solutes and ions across membranes. To discover which transporters are vital for survival as intracellular amastigote forms, we carried out a systematic loss-of-function screen of the L.

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Article Synopsis
  • Histone Deacetylase 1 (HDAC1) removes acetyl groups from histones, impacting gene expression regulation, but its suppression leads to both increases and decreases in gene activity.
  • The study used the dTAG system for rapid HDAC1 degradation in mouse embryonic stem cells, which allowed for specific removal within less than an hour.
  • After HDAC1 degradation, most differentially expressed genes were upregulated within two hours, and changes in histone acetylation patterns indicated HDAC1's complex role in managing gene expression and enhancer activity for maintaining pluripotency.
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