Publications by authors named "S P Bondarenko"
Article Synopsis
- A new method was created to trap certain chemical intermediates (benzopyrone-based ortho-quinone methides) using 3- and 5-amino pyrazoles or isoxazoles.
- Various hybrid compounds were synthesized from natural phenolic Mannich bases and flavonoids, such as coumarin and isoflavone, with moderate to good yields depending on the position of the amino group.
- Some of the resulting compounds, especially those with 5-aminoisoxazole, showed the ability to inhibit α-glucosidase, demonstrating potential biological activity with micromolar IC values.
Article Synopsis
- The COMMODORE trial tested a new drug called gilteritinib against a treatment called salvage chemotherapy for patients with a type of blood cancer (AML) that has a specific gene mutation (FLT3).
- Results showed that patients taking gilteritinib lived longer (9.6 months) than those on chemotherapy (5.0 months) and also stayed healthier for longer without problems (2.8 months vs. 0.6 months).
- Gilteritinib led to fewer severe side effects, with common issues being low red blood cells and low platelet levels, making it a safer option for these patients.
An efficient green approach for the trapping of generated -and -quinone methide intermediates by imidazoles and pyrazoles has been developed. A wide range of quinone methide precursors based on simple phenols are compatible with the experimental protocol under mild thermal conditions. This methodology was demonstrated to be suitable for the synthesis of methylene-linked benzopyrone-azole hybrids using naturally occurring coumarin and chromone Mannich bases.
View Article and Find Full Text PDF[The clinical case of IgG4-related thyroid disease in a 6-year-old child].
Probl Endokrinol (Mosk)
October 2023
Article Synopsis
- IgG4-related disease is a rare chronic condition characterized by infiltration of tissues, fibrosis, and elevated IgG4 levels, affecting less than 1 in 100,000 people annually.
- It was recognized as a distinct disease in 2001 and can impact various organs, including its association with Riedel's thyroiditis established in 2010.
- Riedel's thyroiditis is an exceptionally rare inflammatory thyroid disease with complex diagnosis, and there have been fewer than 300 reported cases globally, including only two in children.