Publications by authors named "S P Becerra"

Article Synopsis
  • The study investigated the use of transcranial focused ultrasound (tfUS) to treat patients with treatment-refractory generalized anxiety disorder (trGAD) by targeting the right amygdala.
  • Twenty-five participants received eight weekly tfUS sessions and were assessed using anxiety measures such as the Hamilton Anxiety Inventory (HAM-A) and Beck Anxiety Inventory (BAI), showing significant reductions in anxiety levels post-treatment.
  • The findings indicate that tfUS is a safe and potentially effective intervention for anxiety disorders, meriting further research into its applications for psychiatric and neurological conditions.
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Background: Chile has made significant progress in recent decades in implementing policies to improve the efficiency of its health system with an impact on population health.

Aim: To present five case studies of successful policies whose impact has been documented.

Methods: Case study report.

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Photoreceptor death causes blinding inheritable retinal diseases, such as retinitis pigmentosa (RP). As disease progression often outpaces therapeutic advances, finding effective treatments is urgent. This study focuses on developing a targeted approach by evaluating the efficacy of small peptides derived from pigment epithelium-derived factor (PEDF), known to restrict common cell death pathways associated with retinal diseases.

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Background: The amygdala is highly implicated in an array of psychiatric disorders but is not accessible using currently available noninvasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) is a neuromodulatory technique that has the capability of reaching subcortical regions noninvasively.

Methods: We studied healthy older adult participants ( = 21, ages 48-79 years) who received TFUS targeting the right amygdala and left entorhinal cortex (active control region) using a 2-visit within-participant crossover design.

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Background: Alzheimer's disease (AD) is a progressive, multifactorial, neurodegenerative disorder affecting >6 million Americans. Chronic, low-grade neuroinflammation, and insulin resistance may drive AD pathogenesis. We explored the neurophysiological and neuropsychological effects of NE3107, an oral, anti-inflammatory, insulin-sensitizing molecule, in AD.

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