Publications by authors named "S P Bairamova"
Article Synopsis
- * A case-control study was conducted on 2393 individuals in Russia, focusing on four genetic polymorphisms to explore their association with various mental disorders and schizophrenia specifically.
- * Significant genetic associations were found, suggesting a genetic basis for mental disorders in the Russian population, which may enhance future psychiatric diagnostic methods.
[The relationship of cytochrome P450 isoforms with the efficacy and safety of antipsychotic and antidepressant therapy].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2023
Cytochrome P450 (CYP450) is the leading enzyme in the biotransformation of most psychotropic drugs. CYP450 gene polymorphisms determine a patient's endophenotype with respect to the activity of enzymes of the family and affect the metabolism of prescribed antipsychotics and antidepressants. Categorizing patients by endophenotype during genotyping is likely to help simplify the selection of therapy in clinical practice.
View Article and Find Full Text PDF[A role of neurosteroids in the pathogenesis of psychiatric disorders].
Zh Nevrol Psikhiatr Im S S Korsakova
April 2023
Despite the proven importance of neurosteroids in many physiological processes, their role in the pathogenesis of the most of psychiatric disorders remains relatively understudied. This article reviews the current clinical evidence on the effects of neurosteroids on the formation and treatment of anxiety disorder, depression, bipolar disorder, and schizophrenia. In particular, the article points out the ambivalent nature of the effects of neurosteroids on GABA- and other receptors.
View Article and Find Full Text PDFIntroduction: The aim of this prospective randomized study was to compare the efficacy and safety of catheter ablation (CA) versus surgical ablation (SA) in the treatment of paroxysmal and persistent AF after failed initial pulmonary vein isolation procedure.
Methods And Results: Patients with a history of symptomatic AF after a previous failed first ablation procedure were eligible for this study. Patients were randomized to CA (n = 32) or SA (n = 32) redo ablation.
Article Synopsis
- The study compared the effectiveness of early reablation versus antiarrhythmic drug (AAD) therapy in patients with prior failed pulmonary vein isolation for treating paroxysmal atrial fibrillation (AF).
- Out of 154 patients with symptomatic AF recurrences, those who underwent reablation showed significantly better outcomes, with only 25% experiencing AF progression compared to 79% in the AAD group.
- At the end of the follow-up period, a much higher percentage of patients in the reablation group were free of AF or atrial tachycardia (58% vs. 12%), indicating that reablation is a more effective treatment option.