Publications by authors named "S P Aiken"

Purpose: This umbrella review synthesizes and discusses systematic reviews (SRs) and meta-analyses (MAs) on auditory outcomes associated with COVID-19 infection and vaccination side effects. It is innovative in offering a comprehensive synthesis of evidence across adults and infants while summarizing vaccine-related auditory side effects.

Method: This literature search followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, with no restrictions on population age or symptom severity.

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Article Synopsis
  • Multispecies biofilm orthopedic infections are harder to treat than infections caused by a single species, prompting this study to explore effective treatment options.
  • The research tested a combination of high purity antibiotic-loaded calcium sulfate beads (HP-ALCSB) with antibiotics vancomycin and tobramycin against a mixed biofilm of Gram-negative and Gram-positive bacteria.
  • Results showed that the combination treatment significantly reduced biofilm growth and surviving resistant bacteria by 50% compared to using the antibiotics separately, suggesting that combined antibiotic therapies may be more beneficial for tackling multispecies biofilms.
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Second autopsies are uncommon in the United States yet are of significant public value. A second autopsy may be sought when the first autopsy findings are disputed, considered biased, or inadequately communicated. Second autopsies are technically and interpretatively difficult and usually rely heavily on investigative information, first autopsy findings, and additional documentation from the first autopsy.

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Polyketide natural products often contain common repeat motifs, for example, propionate, acetate and deoxypropionate, and so can be synthesized by iterative processes. We report here a highly efficient iterative strategy for the synthesis of polyacetates based on boronic ester homologation that does not require functional group manipulation between iterations. This process involves sequential asymmetric diboration of a terminal alkene, forming a 1,2-bis(boronic ester), followed by regio- and stereoselective homologation of the primary boronic ester with a butenyl metallated carbenoid to generate a 1,3-bis(boronic ester).

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The influence of male and female vowel characteristics on the envelope-following responses (EFRs) is not well understood. This study explored the role of vowel characteristics on the EFR at the fundamental frequency (f0) in response to the vowel /ε/ (as in "head"). Vowel tokens were spoken by five males and five females and EFRs were measured in 25 young adults (21 females).

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