Publications by authors named "S Ozdamar"
The primary aim of this study was to explore the impact of diabetes on matrix metalloproteases and tissue inhibitors, crucial factors for successful implantation, and to elucidate the molecular mechanisms that undergo changes in the endometrium and the embryo during diabetic pregnancies. In this investigation, we established a streptozotocin-induced diabetic pregnant rat model. Microarray analysis followed by RT-PCR was utilized to identify gene regions exhibiting expression alterations.
View Article and Find Full Text PDFEffects of adriamycin on cell differentiation and proliferation in rat testis.
Biotech Histochem
November 2023
Article Synopsis
- Adriamycin (ADR), a cancer treatment, harms healthy organs like the testis, prompting a study on its effects on pluripotency in rat testis.
- Rats were split into three groups: untreated control, cumulative dose ADR, and single dose ADR, with various evaluations conducted for testicular damage and spermatogenic cell marker expressions.
- Results showed decreased seminiferous tubule diameters, lower expression of key pluripotency markers, and reduced testosterone levels in both ADR-treated groups, indicating ADR's detrimental impact on testicular function and maintenance of pluripotency.
Radiotherapy is one of the inevitable treatment approaches for several types of cancer. We aimed to show the protective and therapeutic effects of daily use of melatonin on liver tissues subjected to a single dose of 10 Gy (gamma-ray) total body radiation. Rats were divided into 6 groups, of which 10 were in each: control, sham, melatonin, radiation, radiation+melatonin, and melatonin+radiation.
View Article and Find Full Text PDFArticle Synopsis
- Paclitaxel is a common cancer treatment known to harm the male reproductive system, prompting research into ways to mitigate its toxic effects using antioxidants like curcumin.
- A study involving 40 male rats tested the protective effects of curcumin against paclitaxel-induced testicular damage, comparing different treatment groups (control, curcumin only, paclitaxel only, and a combination of curcumin and paclitaxel).
- Results showed that curcumin significantly reduced testicular damage and improved testosterone levels in the group receiving both curcumin and paclitaxel, indicating a potential protective role for curcumin in mitigating paclitaxel's adverse effects on the testes.
Article Synopsis
- This study focused on how TGF-B1-transfected adipose-derived mesenchymal stem cell (AD-MSC) conditional medium (TGF-B1-CM) affects CD44 expression and the behaviors of two breast cancer cell lines: MCF-7 and MDA-MB-231.
- The researchers treated these cell lines with different media and proteins, analyzing their effects on various biological activities such as cell proliferation, migration, and apoptosis using methods like Western blotting and the Muse Cell Analyzer.
- Results showed that TGF-B1-CM activated the smad signaling pathway, decreased CD44 expression, increased cell apoptosis, reduced proliferation, and hindered cell migration in