Publications by authors named "S Ozcan Bulut"
Aim: The current study aimed to investigate the protective effects of adenosine triphosphate (ATP), metyrosine, and melatonin on possible methylphenidate cardiotoxicity in rats using biochemical and histopathological methods.
Methods: Thirty rats were separated into five groups: healthy (HG), methylphenidate (MP), ATP + methylphenidate (ATMP), metyrosine + methylphenidate (MSMP), and melatonin + methylphenidate (MLMP). ATP (5 mg/kg) was given intraperitoneally once daily, metyrosine (50 mg/kg) orally twice daily, and melatonin (10 mg/kg) orally once daily.
Article Synopsis
- * Sixty-three patients on SNRIs (venlafaxine, duloxetine) and sixty patients on SSRIs underwent assessments, showing that SSRI users had lower bone density values compared to SNRI users, who demonstrated normal bone density.
- * The findings suggest that SNRIs, particularly duloxetine, may pose a lower risk for osteoporosis compared to SSRIs, indicating the need for more research to confirm these results.
The effect of methylphenidate on the reproductive function of female rats.
J Obstet Gynaecol Res
January 2025
Aim: Research on the effects of methylphenidate on female fertility is limited. This study evaluated the effects of methylphenidate on reproductive function, oxidants, antioxidants, proinflammatory cytokines, prolactin, and cortisol in female rats.
Methods: Forty-eight albino Wistar female rats were divided into four groups consisting of 12 rats, which were given pure water orally once daily for 7 days (HG-1), 10 mg/kg methylphenidate orally once daily for 7 days (MP-1), pure water orally once daily for 30 days (HG-2), and 10 mg/kg methylphenidate orally once daily for 30 days (MP-2).
Background: The toxic effects of doxorubicin and cisplatin in various organs have been associated with oxidative stress. Studies have shown that Usnea longissima has strong antioxidant effects. This study aimed to investigate the protective effect of ethyl acetate extract from Usnea longissima (ULE), which is known to have strong antioxidant effects, on chemotherapeutic-induced heart, kidney, liver, and ovarian toxicity.
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- Amiodarone can cause kidney damage by increasing free oxygen radicals and inflammatory markers while decreasing ATP levels, negatively affecting renal function.
- A study on rats examined the protective effects of Coenzyme Q10 (CoQ10), cinnamon extract (CE), and a combination of both (CoCE) against this kidney injury caused by amiodarone.
- Results showed that CoQ10, CE, and CoCE significantly reduced kidney damage, with CoCE being the most effective at preventing oxidative and inflammatory injury.