Temporal Sequence of Incident Mild Cognitive Impairment, Incident Parkinsonism, and Risk of Death in Unimpaired Community-Dwelling Older Adults.

Background: Mild cognitive impairment (MCI) and parkinsonism affect many older adults. The objective of this study was to determine the sequence of their occurrence and associated risk of death.

Methods: A total of 1255 community-dwelling unimpaired participants from 2 epidemiological cohorts were examined annually.

Association of Vascular Risk With Severe vs Non-Severe Stroke: An Analysis of the INTERSTROKE Study.

Background And Objectives: Acute stroke is associated with a spectrum of functional deficits. The objective of this analysis was to explore whether the importance of individual risk factors differ by stroke severity, which may be of relevance to public health strategies to reduce disability.

Methods: INTERSTROKE is an international case-control study of risk factors of first acute stroke (recruitment 2007-August 2015) in 32 countries.

Mobility Abilities Mediate the Association of a More Active Lifestyle With Mobility Disability in Older Adults.

Background: Few studies have analyzed sensor-derived metrics of mobility abilities and total daily physical activity (TDPA). We tested whether sensor-derived mobility metrics and TDPA indices are independently associated with mobility disabilities.

Methods: This cohort study derived mobility abilities from a belt-worn sensor that recorded annual supervised gait testing.

Carbonated Beverage, Fruit Drink, and Water Consumption and Risk of Acute Stroke: the INTERSTROKE Case-Control Study.

Background And Purpose: Cold beverage intake (carbonated drinks, fruit juice/drinks, and water) may be important population-level exposures relevant to stroke risk and prevention. We sought to explore the association between intake of these beverages and stroke.

Methods: INTERSTROKE is an international matched case-control study of first stroke.

Motor and Nonmotor Measures and Declining Daily Physical Activity in Older Adults.

Importance: Difficulties in identifying modifiable risk factors associated with daily physical activity may impede public health efforts to mitigate the adverse health outcomes of a sedentary lifestyle in an aging population.

Objective: To test the hypothesis that adding baseline sensor-derived mobility metrics to diverse baseline motor and nonmotor variables accounts for the unexplained variance of declining daily physical activity among older adults.

Design, Setting, And Participants: This cohort study analyzed data from participants of the Rush Memory and Aging Project (MAP), an ongoing longitudinal clinical pathological study that began to enroll older adults (age range, 59.