Publications by authors named "S Oscarson"
Article Synopsis
- A study highlights the development of two semisynthetic vaccine candidates targeting a fungus that poses serious risks to immunocompromised patients, focusing on its key polysaccharide, glucuronoxylomannan (GXM).
- The vaccines, containing a synthetic decasaccharide antigen (M2 motif), were conjugated to two proteins and tested in mice, showing specific immune responses and some cross-reactivity to other GXM variants.
- While one glycoconjugate showed potential for increased survival in mice, further optimizations are needed before it can be considered for a multivalent GXM vaccine.
Published work has shown that glycoconjugate vaccines, based on truncated detoxified lipopolysaccharides from Moraxella catarrhalis attached through their reducing end to a carrier protein, gave good protection for all three serotypes A, B, and C in mice immunisation experiments. The (from the non-reducing end) truncated LPS structures were obtained from bacterial glycosyl transferase knock-out mutants and contained the de-esterified Lipid A, two Kdo residues and five glucose moieties. This work describes the chemical synthesis of the same outer Moraxella LPS structures, spacer-equipped and further truncated from the reducing end, i.
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- A fungus classified as a critically important pathogen by the WHO poses a serious threat to immunocompromised individuals, motivating research on potential vaccines.
- The study focuses on two semi-synthetic glycoconjugate vaccines that target a specific capsular polysaccharide (GXM) common in most cryptococcosis cases, created by conjugating a synthetic decasaccharide antigen to two different proteins.
- Immunization in mice showed promising results with one glycoconjugate leading to increased survival rates and specific antibody responses, although more optimization is needed for it to become part of a broader vaccine strategy.
is a fungal pathogen responsible for cryptococcosis and cryptococcal meningitis. The ' capsular polysaccharide and its shed exopolysaccharide function both as key virulence factors and to protect the fungal cell from phagocytosis. Currently, a glycoconjugate of these polysaccharides is being explored as a vaccine to protect against infection.
View Article and Find Full Text PDFThe synthesis of gram quantities of the TF antigen (β-ᴅ-Gal-(1→3)-α-ᴅ-GalNAc) and its 3'-sulfated analogue with a TEG-N spacer attached is described. The synthesis of the TF antigen comprises seven steps, from a known -Troc-protected galactosamine donor, with an overall yield of 31%. Both the spacer (85%) and the galactose moiety (79%) were introduced using thioglycoside donors in NIS/AgOTf-promoted glycosylation reactions.
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