Publications by authors named "S Osanai"
The patient, a 56-year-old lady, also exhibited numerous lymphadenopathy, hepatosplenomegaly, hyperleukocytosis (167,200/µl, aberrant lymphocytes 91.5%), and fever. A lymph node biopsy revealed follicular lymphoma (FL), grade 1.
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- A 79-year-old man with primary plasma cell leukemia experienced multiple extramedullary plasmacytomas and developed thrombotic microangiopathy (TMA) after starting treatment with carfilzomib, lenalidomide, and dexamethasone (KLd).
- After the diagnosis of TMA on day 7 of treatment, KLd therapy was stopped, leading to improvement in TMA symptoms, indicating a strong link between the drug and the condition.
- After reducing the dose of KLd and achieving a very good partial response (VGPR), the patient has remained in remission, suggesting that dose adjustment for patients experiencing TMA might be a viable option in effective treatments.
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- The study focused on the role of PRAME (preferentially expressed antigen in melanoma) in bone marrow cells from 116 patients with myelodysplastic syndromes (MDS).
- High levels of PRAME expression were linked to worse survival rates in MDS patients, particularly those with low bone marrow blast percentages and lower IPSS-R risk categories.
- The findings indicate that PRAME could serve as a potential prognostic factor for assessing disease progression and outcomes in MDS patients.
We herein report two cases of thrombotic thrombocytopenic purpura (TTP) complicated by other autoimmune disorders, autoimmune hepatitis and immune thrombocytopenia, respectively. In both cases, corticosteroids were continuously administered for the treatment of preceding autoimmune disorders. However, a sufficient objective response for TTP was not obtained by plasma exchange and corticosteroid treatment.
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