Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice.

Patients receiving cranial radiation therapy experience tissue damage and cognitive deficits that severely decrease their quality of life. Experiments in rodent models show that these adverse neurological effects are in part due to functional changes in microglia, the resident immune cells of the central nervous system. Increasing evidence suggests that experimental manipulation of microglial signaling can regulate radiation-induced changes in the brain and behavior.

Cortical microglia dynamics are conserved during voluntary wheel running.

We present the first demonstration of chronic in vivo imaging of microglia in mice undergoing voluntary wheel running. We find that healthy mice undergoing voluntary wheel running have similar microglia dynamics, morphologies, and responses to injury when compared to sedentary mice. This suggests that exercise over a period of 1 mo does not grossly alter cortical microglial phenotypes and that exercise may exert its beneficial effects on the brain through other mechanisms.

Primary school children's participation in selecting children's nursing students.

Despite the importance of seeking children's views in healthcare being widely recognised, there are few reports of child service user involvement in selecting children's nursing students. At Oxford Brookes University, the children's nursing team has had three years' experience of partnership with a local primary school where children have engaged in the selection of children's nursing students. At the end of the first year of the initiative an evaluation was undertaken to elicit the children's views about their experience of participating in an interview day.

The US National Seed Strategy for Rehabilitation and Restoration: progress and prospects.

The National Seed Strategy for Rehabilitation and Restoration was developed by a partnership of 12 federal agencies and over 300 non-federal cooperators in the United States and launched in 2015. Implementation aims to ensure the availability of genetically appropriate native seed for ecological restoration across the country. Ecological restoration is required in response to a wide range of human impacts.

The effect of dietary neonicotinoid pesticides on non-flight thermogenesis in worker bumble bees (Bombus terrestris).

For bumble bees (genus Bombus), the capacity for non-flight thermogenesis is essential for two fundamental processes undertaken by adult workers, namely recovery from torpor after chilling and brood incubation. Farmland bees can be widely exposed to dietary residues of neurotoxic neonicotinoid insecticides that appear in the nectar and pollen of treated bee-attractive crops, which may harm them. An earlier study shows that dietary neonicotinoids cause complex alterations to thermoregulation in honey bees, but their effect on the thermogenic capabilities of individual bumble bees has been untested previously.