Publications by authors named "S Ohni"
Article Synopsis
- The study investigated the long-term outcomes of patients with hepatitis C virus (HCV)-related liver cancer (HCC) who underwent surgery, focusing on those who achieved sustained virologic response (SVR) from antiviral therapy versus those who didn't.
- A total of 216 patients were analyzed, revealing that those with pre- or post-SVR had better liver health and significantly improved overall survival (OS) and recurrence-free survival (RFS) compared to the non-SVR group.
- Results suggested that achieving SVR, particularly through direct-acting antiviral (DAA) therapy, was strongly linked to lower recurrence rates and increased survival rates after surgical resection of HCC.
Article Synopsis
- Primary testicular lymphoma (PTL) is rare, and patients often receive radiation therapy to the contralateral testis to prevent relapse after achieving remission.
- A 76-year-old man treated for PTL developed a new mass in the glans penis 6.5 years later, prompting investigation into whether it was a relapse or a new cancer.
- Genomic analysis revealed that the penile lymphoma shared genetic similarities with the original PTL, confirming it as a relapse, marking it as the first reported case of PTL returning in the glans penis.
Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component.
Takahiro Suzuki Yoko Nakanishi Tomoyuki Tanino Haruna Nishimaki-Watanabe Hiroko Kobayashi Sumie Ohni
Discov Oncol
April 2024
Article Synopsis
- - Metaplastic breast carcinoma (MBC) is a diverse type of breast cancer comprised of various histological types, often exhibiting a mix of different cancer cell characteristics, which is important for understanding tumor behavior and managing recurrence.
- - In a study of 25 MBC tumors, the predominant components were found to be squamous cell carcinoma (SCC) and spindle cell carcinoma (SpCC), each exhibiting distinct immunohistochemical markers that could aid in identification and treatment.
- - Analysis revealed that SCC had notable PTEN gene mutations and specific marker expressions compared to SpCC, indicating that these components have unique molecular profiles that could influence prognosis and therapeutic strategies.
To clarify the mechanism underlying the development and poor prognosis of combined hepatocellular-cholangiocarcinoma (cHCC-CCA), we characterized liver cancer driver mutations and poor prognostic markers in both the HCC and intrahepatic CCA (iCCA) components of a cHCC-CCA tumor. The telomerase reverse transcriptase () promoter mutation C228T was quantified by digital polymerase chain reaction using DNA from multiple microdissected cancer components of a single cHCC-CCA nodule. The protein expression of cancer-related markers, including TERT, was examined by serial thin-section immunohistochemistry and double-staining immunofluorescence.
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- * Case 1 responded well to crizotinib for over 5 years, while Case 2 had a shorter survival of 19 months, despite similar Ki67 proliferation rates.
- * Genetic analysis revealed different ROS1 fusion sequences, with higher levels of ROS1 and activated pERK1/2 in Case 2, suggesting these factors might impact therapeutic responses and prognosis.