Publications by authors named "S Oguzkan-Balci"
Article Synopsis
- Migraines are a neurological condition marked by severe headaches, and new research highlights the role of genetic variations, like CNVs and miRNA expression, in understanding and potentially treating this disease.
- A study with migraine sufferers (102 participants) and non-sufferers (120 participants) analyzed various genetic markers alongside clinical parameters, finding significant differences in specific genes and CNV patterns between the two groups.
- The analysis demonstrated that certain genetic markers had good diagnostic power, suggesting they might be used in developing targeted treatments for migraines by modulating pain mechanisms.
Article Synopsis
- Uteroglobin (UG) is a protein with anti-inflammatory effects, and this study investigated the G38A genetic variation's role in childhood idiopathic nephrotic syndrome (INS) and its relation to steroid response.
- One hundred thirty-six children with INS and 70 healthy controls were analyzed, revealing that the AA genotype of the UG gene G38A polymorphism was significantly associated with increased risk of both steroid-sensitive and steroid-resistant INS.
- The findings suggest that the UG gene influences the development of INS, particularly the AA genotype, prompting the need for further research on genetic variations and their impacts in larger populations.
This study aimed to investigate whether functional variants of endothelial nitric oxide synthase (eNOS) gene play any role in rheumatoid arthritis (RA) ethiopathogenesis and treatment in the Turkish population. Because, eNOS variants are responsible for alteration of the NO level in plasma, by reducing/increasing the endothelial NO synthesis. In the study, two eNOS gene variants (G894T and intron 4 VNTR A/B) were examined at extracted DNAs from 65 peripheral blood cell of RA patients.
View Article and Find Full Text PDFIn this study, we aimed to explore the association among gene variants of five cytokines, tumor necrosis factor alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), interferon gamma (IFN-γ), interleukin-6 (IL-6), and interleukin-10 (IL-10), and clinical parameters and prognosis in patients with multiple myeloma (MM) treated with novel therapeutic drugs in Turkish population for the first time except TNF-α. We analyzed five cytokine genes in 113 cases with MM and 113 healthy controls. Cytokine genotyping was performed by the polymerase chain reaction-sequence-specific primer method (PCR-SSP).
View Article and Find Full Text PDFIt is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFα), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasone-cyclophosphamide) and TD (thalidomide-dexamethasone). We analyzed TNFα, NOS 3 and MDR1 in 77 patients with MM and 77 healthy controls.
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