Association between left ventricular reverse remodelling and the B-type natriuretic peptide-cGMP cascade after anterior acute myocardial infarction.

Background: The role of cyclic guanosine 3',5'-monophosphate (cGMP) after acute myocardial infarction (AMI) is not well understood despite its significance as a second messenger of natriuretic peptides (NPs) in cardiovascular disease. We investigated the association between the NP-cGMP cascade and left ventricular reverse remodelling (LVRR) in anterior AMI.

Methods: 67 patients with their first anterior AMI (median age, 64 years; male, 76%) underwent prospective evaluation of plasma concentrations of the molecular forms of A-type and B-type natriuretic peptide (BNP) and cGMP from immediately after primary percutaneous coronary intervention (PPCI) to 10 months post-AMI.

Tetrabutylammonium Chlorite as an Efficient Oxidant for Controlled Oxidation of Sulfides to Sulfoxides.

Considering the demand for organosulfur materials and the challenges associated with currently used oxidation processes, in this study, we evaluated the counter-cation of sodium chlorite (Na+ClO2-) with tetrabutylammonium chloride (Bu4N+Cl-) to synthesise tetrabutylammonium chlorite (Bu4N+ClO2-). Bu4N+ClO2- exhibited good solubility in organic solvents like chloroform (1.6 g mL-1) and ethyl acetate (0.

Masticatory performance indicates the development of psychological frailty: A 6-year prospective cohort study by the SONIC study group.

Purpose: Although the association between oral health and physical frailty is well established, psychological frailty has not been investigated. Therefore, this prospective cohort study was conducted to examine the association between masticatory performance and psychological frailty in older community-dwelling Japanese individuals.

Methods: The participants included 498 older adults who completed baseline and 3- and 6-year follow-up surveys.

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice.

The presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy. Glutathione (GSH) is the body's primary detoxifier and antioxidant, and its oxidized form (GSSG) has been considered as a marker of oxidative status. However, we report that GSSG, but not reduced GSH, prevents ischemic supersulfide catabolism-associated heart failure in male mice by electrophilic modification of dynamin-related protein (Drp1).

Isolation method of brain microvessels from small frozen human brain tissue for blood-brain barrier protein expression analysis.

Background: Protein expression analysis of isolated brain microvessels provides valuable insights into the function of the blood-brain barrier (BBB). However, isolation of brain microvessels from human brain tissue, particularly in small quantities, poses significant challenges. This study presents a method for isolating brain microvessels from a small amount of frozen human brain tissue, adapting techniques from an established mouse brain capillary isolation method.