Publications by authors named "S Ochi"
Aim: Recent studies have implicated autophagy in both weight regulation and depression. This study aimed to investigate the relationship between stress-induced weight loss and autophagy-related gene expression in a mouse model of depression.
Method: Male C57BL/6 mice were subjected to a chronic immobilization stress (CIS) protocol for 14 days to induce depressive-like behavior.
Aim: Constipation is one of the most common adverse effects in schizophrenia treatment, and it can sometimes cause severe gastrointestinal disease. However, the results of association studies between constipation and psychotropic medications in patients with schizophrenia are inconsistent. Therefore, we investigated the characteristics of psychotropic and laxative prescriptions at discharge in patients with schizophrenia to clarify the association between psychotropics and constipation.
View Article and Find Full Text PDFThe frequency of behavioral and psychological symptoms of dementia (BPSD) is high, and it is a challenge to elucidate its neural substrates underlying their development. In recent years, many findings have been reported on the relationship between BPSD and brain volume in dementia patients. However, the results are not fully conclusive.
View Article and Find Full Text PDFArticle Synopsis
- Idiopathic multicentric Castleman disease (iMCD) is a subtype of Castleman disease that is not linked to KSHV/HHV8 and is categorized into three types: iMCD-IPL, iMCD-TAFRO, and iMCD-NOS.
- The primary treatment is IL-6 inhibitors, yet patients with iMCD-TAFRO and NOS often show resistance, indicating the influence of other cytokines in their pathology.
- A transcriptome analysis revealed increased expression of various cytokine-related genes in iMCD-TAFRO/NOS, suggesting enhanced inflammatory signaling pathways, particularly the JAK-STAT and MAPK pathways, contributing to a potential cytokine storm.
Article Synopsis
- - The study examined factors influencing the improvement of health assessment questionnaire-disability index (HAQ-DI) and pain scores in rheumatoid arthritis (RA) patients who achieved low disease activity (LDA) after treatment with biological and targeted-synthetic DMARDs.
- - Data from the FIRST registry highlighted that seropositivity and the use of JAK inhibitors were positively linked to both HAQ-DI normalization and pain score reduction, while older age, history of treatment failures, and higher baseline HAQ-DI were associated with poorer outcomes.
- - The findings suggest that certain treatments may be more effective early on in managing RA, indicating avenues for preventing the condition from becoming difficult to treat.