Publications by authors named "S OKUBO"
Marine natural products show a large variety of unique chemical structures and potent biological activities. Elucidating the target molecule and the mechanism of action is an essential and challenging step in drug development starting with a natural product. Odoamide, a member of aurilide-family isolated from Okinawan marine cyanobacterium, has been known to exhibit highly potent cytotoxicity against various cancer cell lines.
View Article and Find Full Text PDFObjective: This study aimed to examine the characteristics of participation in the self-quantification program for family caregivers (CGs) who provide long-term care to community-dwelling older adults. The family CGs, allocated based on the percentage of the nation's older population who needed care and met the inclusion criteria, who provided caregiving at least once a week for those aged 65 + and who were certified as needing care under the Japanese long-term care insurance program, were collected through online monitors. We compared the characteristics of the program participants and nonparticipants using logistic regression.
View Article and Find Full Text PDFIntroduction: Introduction of new systemic therapies for hepatocellular carcinoma (HCC) has led to the development of new oncological criteria of resectability for the resectability of HCC. This study was aimed at validating the prognosticating ability and clinical utility of the resectability classification based on the novel criteria in real-world clinical practice.
Methods: This study was conducted in 1,822 patients who had undergone curative resection for HCC (population 1) and 107 patients with unresectable disease who had received lenvatinib therapy (population 2).
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron disease, with recent connections made between variants in the SPTLC1 gene and both hereditary neuropathy and juvenile ALS.
- The study analyzed genetic data from patients with familial and sporadic ALS to assess the presence and effects of SPTLC1 variants, using techniques like RT-PCR and ddPCR to evaluate splicing and genetic mosaicism.
- A specific SPTLC1 variant was found in a 21-year-old female patient with juvenile ALS, inherited from her asymptomatic father who exhibited a mosaic form of the variant, highlighting the need for further exploration of the clinical implications of such mosaicism.
Article Synopsis
- - Groove pancreatic cancer is a malignant tumor that forms in the area where the pancreas, duodenum, and bile duct meet, and it can be difficult to differentiate from groove pancreatitis due to similar symptoms and imaging results.
- - A 54-year-old male patient experienced severe gastrointestinal symptoms and imaging showed a problematic lesion near the pancreas, but doctors were unable to confirm malignancy before surgery.
- - After surgical intervention, the diagnosis of groove pancreatic adenocarcinoma was confirmed, but despite treatment, the patient passed away 17 months later, highlighting the need to consider groove pancreatic cancer in similar cases.