Thermoheliox: effect on the functional hemodynamics of the human brain.

A kinetic study of the effect of thermoheliox (inhalation of a helium and oxygen mixture, 70 °C) on the functional hemodynamics of the human brain by functional magnetic resonance imaging was carried out. The dynamic responses of the BOLD signal were found to be biphasic. An empirical equation describing the first phase of the hemodynamic response to visual stimulus was proposed.

Supercomputer simulation of the covalent inhibition of the main protease of SARS-CoV-2.

Molecular modeling tools were applied to design a potential covalent inhibitor of the main protease (M) of the SARS-CoV-2 virus and to investigate its interaction with the enzyme. The compound includes a benzoisothiazolone (BZT) moiety of antimalarial drugs and a 5-fluoro-6-nitropyrimidine-2,4(1.,3)-dione (FNP) moiety mimicking motifs of inhibitors of other cysteine proteases.

Dynamics of the Multipathway Regulation of the Vasodilator Bold Effect Induced by a Nerve Impulse: A Kinetic Model of the Neurovascular Coupling Process.

A kinetic model of the dynamics of a multipathway mechanism of neurovascular coupling induced by nerve impulses was constructed. The model calculations were compared with experimental data on the changes in the blood oxygen level dependent signal during sensory-motor and visual excitation before and after the use of the nonsteroidal anti-inflammatory drug indomethacin. The influence of the catalytic activity of key enzymes on the dynamics of the neurovascular response in the proposed model is shown.

Thermovaccination: Thermoheliox as an Immune Response Stimulant. Kinetics of Antibodies and C-Reactive Protein Synthesis in Coronaviral Infection.

The high efficiency of using thermoheliox (inhalation with a high-temperature mixture of helium and oxygen) in the treatment of patients affected by COVID-19 was shown. The dynamics of accumulation of IgG, IgM, and C-reactive protein (CRP) in patients with coronavirus infection in the "working" and control groups was studied experimentally. It was shown that thermoheliox intensifies the synthesis of IgG, IgM, and CRP antibodies, while eliminating the induction period on the kinetic curves of the synthesis of specific antibodies in the IgG form and transfers the synthesis of CRP to a fast phase.

3T MEGA-PRESS study of N-acetyl aspartyl glutamate and N-acetyl aspartate in activated visual cortex.

Objective: To measure N-acetyl aspartyl glutamate (NAAG) and N-acetyl aspartate (NAA) concentrations in visual cortex activated by a continuous stimulation in a 3 T field.

Methods: NAAG and NAA spectra were obtained with MEGA-PRESS pulse sequence (TE/TR = 140/2000 ms; δ/δ = 4.61/4.