Publications by authors named "S O Sykes"
Fatty acids are essential biomolecules that support several cellular processes, such as membrane structures, energy storage and production, as well as signal transduction. Accordingly, changes in fatty acid metabolism can have a significant impact on cell behavior, such as growth, survival, proliferation, differentiation, and motility. Therefore, it is not surprising that many aspects of fatty acid metabolism are frequently dysregulated in human cancer, including in highly aggressive blood cancers such as acute leukemia.
View Article and Find Full Text PDFThis commentary is intended as a response to ongoing concerns expressed about fundamental limitations of current research, policy, and practice surrounding health literacy. These concerns emphasise the individualistic and reductionist approaches which often dominate health literacy work, as well as a neglect of broader structural factors in addressing pressing public health issues. The potential of critical health literacy as a concept and practical approach which responds to these critiques is presented.
View Article and Find Full Text PDFArticle Synopsis
- - Communities of Practice (CoPs) show promise in enhancing community-centered health promotion, specifically in addressing gambling harms among voluntary, community, faith, and social enterprises (VCFSE) in a city-region in England.
- - The evaluation included 33 qualitative interviews and focused on building a mid-level program theory, revealing that the CoP helped foster community interventions through staff understanding and collaboration, despite inconsistencies in project-level outcomes.
- - Ultimately, CoPs proved effective alongside VCFSE projects and individuals with lived experience, contributing to a knowledge base that supports the government's strategy for reducing gambling-related issues.
Aims And Method: The aim was to evaluate an innovative pathway in police custody suites that aimed to specifically address alcohol-related health needs through screening and brief interventions by police custody staff. This paper presents a qualitative investigation of challenges involved in implementing the pathway. Qualitative interviews were carried out with 22 staff involved with commissioning and delivering the pathway; thematic analysis of interview data was then undertaken.
View Article and Find Full Text PDFPurpose: Somatic missense mutations in the phosphodegron domain of the MYC gene (MYC Box I or MBI) are detected in the dominant clones of a subset of patients with acute myeloid leukemia (AML), but the mechanisms by which they contribute to AML are unknown.
Experimental Design: To investigate the effects of MBI MYC mutations on hematopoietic cells, we employed a multi-omic approach to systematically compare the cellular and molecular consequences of expressing oncogenic doses of wild type, threonine-58 and proline-59 mutant MYC proteins in hematopoietic cells, and we developed a knockin mouse harboring the germline MBI mutation p.T58N in the Myc gene.