Exploring Serotonergic Psychedelics as a Treatment for Personality Disorders.

Both psychotherapeutic interventions and pharmacological agents have demonstrated limited efficacy in the treatment of personality disorders (PDs). Emerging evidence suggests that psychedelic therapy, already showing promise in treating various psychiatric conditions commonly comorbid with PDs, may exert therapeutic effects by promoting adaptive changes in personality. Thus, psychedelic therapy could hold potential for addressing core features of PDs through shared mechanisms of personality modulation.

In Science Journals.

Highlights from the family of journals.

Extracted Spent Coffee Grounds as a Performance-Enhancing Additive for Poly(Lactic Acid) Biodegradable Nursery Bags in Agriculture.

This study introduces biodegradable nursery bags using poly(lactic acid) (PLA), a widely used biodegradable polymer, and spent coffee grounds (SCGs), a byproduct of the brewing process in the coffee industry. SCGs were oil-extracted to produce extracted spent coffee grounds (exSCGs), which were characterized by their physical properties, chemical functionality, and thermal behavior. The exSCGs were blended with PLA at loadings of 5, 10, and 15 wt%.

Effects of Therapeutic Antibiotic Exposure on the Oropharyngeal and Fecal Microbiota in Infants With Cystic Fibrosis.

Background: Systemic antibiotics can impact all microbes inhabiting patients, regardless of the intended target organism(s). We studied the simultaneous effects on respiratory and fecal microbiomes of β-lactam antibiotics administered for respiratory symptoms in infants with cystic fibrosis (IWCF).

Objective: To compare the magnitude and duration of intended (respiratory) and unintended (fecal) antimicrobial action by analyzing oropharyngeal (OP) and fecal microbiota in IWCF.

Robotic Resection of Left Intraductal Papillary Cholangiocarcinoma with Roux-en-Y Hepaticojejunostomy: Standardized Technique of Liver Resection with Biliary Reconstruction.

Background: Intraductal papillary cholangiocarcinoma is a preinvasive type of biliary tract cancer with a relatively favorable prognosis, requiring complete resection of the involved bile ducts and corresponding liver segments (Christodoulou et al. in J Gastrointest Surg, 2024; Sucandy et al. in Collab Study Ann Surg Oncol 31:81-89, 2024; Magistri et al.