Publications by authors named "S O Nikhitha"
Herein, we report the synthesis and anticancer properties of 21 new 1,3,4-thiadiazole-2-yl-imino-thiazolidine-4-one containing binary heterocyclic molecules. Cytotoxicity of the synthesized molecules was evaluated on various cancer cell lines (MCF-7, PC3, 4T1, MDA-MB-231, and MOC2) and normal human embryonic cell lines (HEK-293) MTT assay. The cytotoxicity data of developed compounds was compared with the reference anticancer molecule BG45, a selective inhibitor of the HDAC3 enzyme.
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- The study focuses on designing and synthesizing a new series of 4-(trifluoromethyl)isoxazoles and testing their effectiveness as anti-cancer agents against specific cancer cell lines (MCF-7, 4T1, and PC-3).
- A new metal-free synthetic method was developed to create these challenging molecules using easily available ingredients, overcoming past limitations in synthesis.
- Among the synthesized compounds, one molecule (2g) showed superior anti-cancer activity, being significantly more effective than its non-trifluoromethylated counterpart, indicating that the trifluoromethyl group is crucial for enhancing cancer-fighting properties.
The aim of this study was to test practical solutions to improve biogas yield during the anaerobic digestion of water hyacinth (WH) biomass. Increasing the WH (whole plant) solid content to ∼40% through sun drying (6 h), and its subsequent digestion increased biogas yield by 14% with a higher biogas methane (75%) content. Ensilation of dried WH (40% moisture) was found effective for its preservation to ensure its continuous availability even during offseasons, but the biogas yield from six months ensilated biomass was 20% less compared with fresh WH.
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