Update on Cancer Screening Recommendations for Individuals with Li-Fraumeni Syndrome.

Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition condition characterized by a high lifetime risk for a wide spectrum of malignancies associated with germline pathogenic/likely pathogenic (P/LP) variants in the TP53 tumor suppressor gene. Secondary malignant neoplasms are particularly common. Early cancer detection through surveillance enables early intervention and leads to improved clinical outcomes with reduced tumor-related mortality and treatment-related morbidity.

Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.

Unlabelled: Light-gated ion channels from protists (channelrhodopsins or ChRs) are optogenetic tools widely used for controlling neurons and cardiomyocytes. Multiplex optogenetic applications require spectrally separated molecules that must be found in nature, as they are difficult to engineer without disrupting channel function. Scanning numerous sequence databases, we identified three robust naturally blue-shifted ChRs from ancyromonads.

Efficacy of Pomalidomide on Motor Performance and Functional Abilities in Patients with Steroid Refractory Chronic Graft versus Host Disease: A Randomized Clinical Study.

Background: Deficits in motor performance and functional abilities represent a severe complication for individuals with steroid refractory chronic graft versus host disease (cGVHD) and is associated with decreased survival and high morbidity.

Objective: Characterize the impact of pomalidomide on motor and functional outcomes in patients with cGVHD.

Study Design: Thirty-four adult patients with cGVHD were enrolled in a randomized and unblinded trial.

A Systems Biology Approach of Quantifying Signal Transduction to B-Cell Proliferation and Differentiation.

Combining mathematical modeling with experiments enables quantitative understanding of cell signaling, transcriptional regulation, and cell fate decisions. Here, we provide a systems biology approach to link signal transduction with B cells fate decisions, to enable quantitative prediction of B-cell proliferation, and differentiation. We describe methodology to run simulations that reveal how signal transduction regulates gene expression and predicts cell fate decision.

Development of a method for qualitative data integration to advance implementation science within research consortia.

Background: Methods of integrating qualitative data across diverse studies and within multi-site research consortia are less developed than those for integrating quantitative data. The development ofsuchmethods is essential to support the data exchange needed for cross-study qualitative inquiry and given the increasing emphasis on data sharing and open science. We describe methods for qualitative data integration within the National Cancer Institute's Improving the Management of symPtoms During And following Cancer Treatment (IMPACT) Consortium funded by the Cancer Moonshot.