Publications by authors named "S O Ingerpuu"
MUC20 expression marks the receptive phase of the human endometrium.
Reprod Biomed Online
November 2019
Article Synopsis
- Researchers wanted to know how a protein called MUC20 changes in different types of cells in the uterus during the menstrual cycle.
- They looked at data from various studies and used tests to see how much MUC20 is present in the cells during two different phases of the cycle.
- They discovered that MUC20 is mostly found in certain cells when the uterus is ready to receive a fertilized egg, suggesting it could be an important marker for understanding fertility.
Article Synopsis
- * The research aimed to assess how these inhibitors enhance hESC differentiation efficiency compared to just using BMP4 through RNA sequencing over 12 days.
- * Findings showed that inhibiting FGF2 with BMP4 promotes genes related to embryo implantation and HCG-H production, while TGF-β pathway inhibition hampers trophoblast-like cell formation.
Laminin isoforms laminin-511 and -521 are expressed by human embryonic stem cells (hESC) and can be used as a growth matrix to culture these cells under pluripotent conditions. However, the expression of these laminins during the induction of hESC differentiation has not been studied in detail. Furthermore, the data regarding the expression pattern of laminin chains in differentiating hESC is scarce.
View Article and Find Full Text PDFIntroduction: Dupuytren's contracture (DC) is a chronic fibroproliferative disease of the hand, which is characterized by uncontrolled proliferation of atypical myofibroblasts at the cellular level. We hypothesized that specific areas of the DC tissue are sustaining the cell proliferation and studied the potential molecular determinants that might contribute to the formation of such niches.
Methods: We studied the expression pattern of cell proliferation marker Ki67, phosphorylated AKT (Ak mouse strain thymoma) kinase, DC-associated growth factors (connective tissue growth factor (CTGF), basic fibroblast growth factor (bFGF), insulin-like growth factor 2 (IGF-2)) and extracellular matrix components (laminins, fibronectin, collagen IV) in DC tissue and normal palmar fascia using immunofluorescence microscopy and quantitative real-time polymerase chain reaction (qPCR).
Understanding how the extracellular matrix impacts the function of cancer stem cells (CSCs) is a significant but poorly understood problem. We report that breast CSCs produce a laminin (LM) 511 matrix that promotes self-renewal and tumor initiation by engaging the α6Bβ1 integrin and activating the Hippo transducer TAZ. Although TAZ is important for the function of breast CSCs, the mechanism is unknown.
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