Cytokeratin 19 (CK19) expression by thyroid neoplasms in a Nigerian tertiary health centre.

Introduction: despite the observed appreciable sensitivity and specificity of the use of CK19 in predicting thyroid malignancies, there is still a paucity of information about its uses in Nigeria. Current information across the world is also scarce. This study was to review the histopathological diagnosis of thyroid neoplasms seen in Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile Ife, using cytokeratin 19 immunohistochemical marker.

Mapping 26 years of climate change research in finance and accounting: a systematic scientometric analysis.

Climate change and climate finance continue to attract substantial research interest in several dimensions and categories through COVID-19 breakout and resulting disruptions were crucial. An in-depth scientometric analysis was undertaken to gain concise insights on evolution and publication trends of this multi-dimensional field. Corpus of 657 articles, extracted from Web of Science from 1995 to 2020, were used to identify networks of co-authorship, keywords, subject categories, institutions, and countries engaged in publishing on climate finance along with co-citation and cluster analysis.

Isotonic, aqueous-based media as simple and suitable test media for short-term Haemonchus placei adult worm motility assay.

The solvating power of test media used in anthelmintic assays is critical to the validity of assay results, especially when evaluating plant extracts. High solutes in media lowers its solvating power, altering the range of concentrations available for investigation and assay performance. To identify simplified, well-tolerated media for adult Haemonchus placei with improved solvating power, we investigated the impact of varying solutions of pH (2.

Gastric organoids: Advancing the study of H. pylori pathogenesis and inflammation.

For decades, traditional in vitro and in vivo models used for the study of Helicobacter pylori infection have relied heavily on the use of gastric cancer cell lines and rodents. Major challenges faced by these methods have been the inability to study cancer initiation in already cancerous cell lines, and the difficulty in translating results obtained in animal models due to genetic differences. These challenges have prevented a thorough understanding of the pathogenesis of disease and slowed the development of cancer therapies and a suitable vaccine against the pathogen.

Homeostasis and Cancer Initiation: Organoids as Models to Study the Initiation of Gastric Cancer.

Gastric cancer represents a significant disease burden worldwide. The factors that initiate cancer are not well understood. Chronic inflammation such as that triggered by infection is the most significant cause of gastric cancer.