Publications by authors named "S O Guthrie"
Purpose: This prospective comparative study aimed to assess the effects on contact lens comfort, dryness, and wear time when symptomatic daily disposable (DD) contact lens (CL) wearers were refit with delefilcon A (DT1) lenses.
Patients And Methods: Thirty five symptomatic DD CL wearers with dry eye disease as determined according to the TFOS DEWS 2 guidelines, were enrolled and completed the study. Participants wore their habitual DD CLs during an initial assessment and were subsequently refit with DT1 for 1 month.
Article Synopsis
- Traumatic Brain Injury (TBI) and Spinal Cord Injury (SCI) significantly contribute to global disabilities, with NDIS support costs for these conditions rising sharply in Australia.
- The study employs a retrospective analysis of linked data from rehabilitation hospitals and the NDIS to investigate the relationship between functional independence during rehabilitation and the resources allocated by NDIS.
- The project has received ethical approval and aims to facilitate smoother transitions for individuals with TBI and SCI into the NDIS through ongoing data analysis.
Purpose: To determine the minimal clinically important difference (MCID) for contact lens (CL)-related subjective responses and explore whether MCID values differ between subjective responses and study designs.
Methods: This was a retrospective analysis of data from seven one-week bilateral crossover studies and 14 one-day contralateral CL studies. For comfort, dryness, vision, or ease of insertion, participants rated on a 0-100 visual analogue scale (VAS) and indicated lens preference on a five-point Likert scale featuring strong, slight, and no preferences.
Article Synopsis
- - Immunoglobin light chain (AL) amyloidosis is a rare disease mainly affecting the heart and kidneys through amyloid fibril buildup, making organ-specific evaluations crucial for understanding the disease's impact and guiding treatment.
- - To promote new treatment developments, the Amyloidosis Forum convened to create guidelines for clinical trials, focusing on identifying effective assessment measures particularly from the insights of the Renal Working Group.
- - Key recommendations include using estimated glomerular filtration rate (eGFR) and proteinuria to determine trial eligibility and track patient responses, while highlighting the importance of timely and accurate evaluation of treatment effects.