Publications by authors named "S Nusair"
Article Synopsis
- Orellanine (OR), a toxic compound found in the Cortinarius orellanus mushroom, primarily affects kidney function, specifically targeting the proximal tubular cells.
- This study aimed to understand the acute toxicity of OR by exposing human Primary Renal Tubular Proximal Epithelial Cells (RPTEC) to a specific dose and analyzing gene expression changes using advanced techniques.
- The results indicated that OR has an inhibitory concentration of 319.2 μg/ml, and its toxicity operates through multiple biological pathways, which could lead to future research on treatments for mushroom poisoning.
Regulations often are imposing long postmortem times before autopsy leading to certain toxicity-unrelated changes in biomarkers, which in turn may affect the reliability of toxicity evaluation during forensic investigations. Since methomyl pesticide shows significant toxicity and is frequently encountered in poisoning cases, the current study evaluated different parameters in methomyl intoxicated rats at three different postmortem intervals (Hour 0, Hour 3 and Hour 6). Eighteen adult Sprague Dawley rats were poisoned with methomyl to simulate actual methomyl poisoning cases.
View Article and Find Full Text PDFAims: Oxidative stress and inflammatory response play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). This study investigated the effects of edaravone in rats with CI-AKI.
Main Methods: Male Sprague Dawley rats were randomly assigned into four groups (n = 11-14/group): control, edaravone (30 mg/kg/day intraperitoneally (IP)), CI-AKI, and edaravone with CI-AKI.
The current work involved monitoring two biomarkers in the plasma of children with ASD: the cofactor thiamine that is involved in neurotransmitters modulation for acetylcholine, and the compound histamine, which acts as a neuromodulator by regulating the release of other neurotransmitters. This is the first report to highlight the potential utilization of plasma levels of the selected two brain-related biomarkers in children with ASD. A total of 43 children with ASD of both genders (age 4-12 years) were involved in this study and compared to age and gender-matched control children ( = 42).
View Article and Find Full Text PDFArticle Synopsis
- Mushroom poisoning, specifically from orellanine in Cortinarius orellanus, poses a significant risk to kidney health, prompting this study to investigate its acute toxicity in rats.
- The research involved measuring the lethal dose of orellanine and comparing kidney function in groups treated with orellanine alone, orellanine plus parsley extract, parsley only, and a control group.
- Results indicated that parsley extract significantly mitigated the harmful effects of orellanine on kidney function, suggesting its potential role in treating mushroom poisoning-related kidney injuries in future studies.