Publications by authors named "S Nseir"
Invasive fungal infections during extracorporeal membrane oxygenation.
Intensive Care Med
December 2024
Objectives: A post hoc analysis used pooled STRIVE/ReSTORE trial data to determine outcomes with rezafungin versus caspofungin by Candida species and antifungal susceptibility.
Methods: The efficacy and safety of once weekly rezafungin 400/200 mg versus once daily caspofungin 70/50 mg was demonstrated in the randomized, double-blind phase 2 STRIVE (NCT02734862) and phase 3 ReSTORE (NCT03667690) trials involving adults with candidaemia and/or invasive candidiasis. In this analysis, data were pooled for patients with a documented Candida infection within 96 hours of randomization who also received ≥1 dose of study drug.
Alpha-1 antitrypsin (A1AT) is the major circulating serine protease inhibitor. Hypersialylated glycoforms (HSG) are produced to boost A1AT anti-inflammatory and anti-protease properties. Their occurrence and prognostic impact outside severe COVID-19 or community-acquired pneumonia are unknown.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how intestinal colonization with multidrug-resistant Enterobacterales (MDRE-IC) affects the risk of bloodstream infections (nE-BSI) in hospitalized patients, finding that MDRE-IC significantly increases this risk.
- - Conducted at a large hospital in 2019, the research involved over 7000 patients, with 11.9% found to have MDRE-IC; those colonized had a higher incidence of nE-BSI compared to non-colonized patients.
- - The results highlight the importance of improving infection control and antibiotic use strategies in hospitals to reduce the risk of bloodstream infections related to MDRE colonization.