Publications by authors named "S Novovic"
Objectives: Activation of type M2 macrophages has been implicated in the pathogenesis of chronic pancreatitis (CP). In a clinical pilot study, we investigated blood-based markers of macrophage activation at different stages of CP.
Methods: We performed a cross-sectional analysis of prospectively collected plasma samples from healthy controls and patients with suspected or definitive CP according to the M-ANNHEIM criteria.
Article Synopsis
- The study investigates pancreatic atrophy in patients with chronic pancreatitis (CP) to establish diagnostic standards and analyze factors affecting the condition.
- Measurements of pancreatic size and associated variables like calcifications were collected from a cohort of 539 CP patients to determine cutoffs for identifying atrophy and its link to exocrine pancreatic dysfunction (EPD).
- Results show that specific pancreatic size measurements are linked to EPD, with male sex, older age, and longer CP duration being significant risk factors for pancreatic atrophy.
Aim: To study social disparity in acute pancreatitis (AP) and chronic pancreatitis (CP).We also aimed at exploring whether an interaction exists between alcohol intake and socioeconomic factors.
Methods: Prospective cohort study based on data from 271 696 men and women participating in the Danish National Health Surveys 2010, and 2013.
Introduction: Opioids used to manage severe pain in acute pancreatitis (AP) might exacerbate the disease through effects on gastrointestinal and immune functions. Methylnaltrexone, a peripherally acting µ-opioid receptor antagonist, may counteract these effects without changing analgesia.
Methods: This double-blind, randomized, placebo-controlled trial included adult patients with AP and systemic inflammatory response syndrome at 4 Danish centers.