Hereditary colorectal cancer syndromes and inflammatory bowel disease: results from a registry-based study.

Purpose: In this study, we investigated the progression of high-grade dysplasia (HGD)/CRC in patients with hereditary colorectal cancer syndromes (HCSS) and concomitant inflammatory bowel diseases (IBDs).

Methods: We described the natural history of a series of patients with confirmed diagnosis of hereditary colorectal cancer syndromes (HCCSs) and concomitant IBDs who were referred to the Hereditary Digestive Tumors Registry at the Fondazione IRCCS Istituto Nazionale dei Tumori of Milan.

Results: Between January 1989 and April 2024, among 450 patients with APC-associated polyposis and 1050 patients with Lynch syndrome (LS), we identified six patients with IBDs (five with UC, one with ileal penetrating CD) and concomitant HCCSs (five with LS, one with APC-associated polyposis).

Efficacy of silver nanoparticles (NPs) and fungal elicitors on the curcuminoid production in Curcuma longa L.

This study investigates the effects of silver nanoparticles (Ag NPs), biogenic silver nanoparticles derived from Rhizopus spp. (R.Ag NPs), and Rhizopus (R) elicitors on the yield and bioactive compounds of turmeric (Curcuma longa) using foliar spray and rhizome dipping techniques.

Environmental Pollutants as Emerging Concerns for Cardiac Diseases: A Review on Their Impacts on Cardiac Health.

Comorbidities related to cardiovascular disease (CVD) and environmental pollution have emerged as serious concerns. The exposome concept underscores the cumulative impact of environmental factors, including climate change, air pollution, chemicals like PFAS, and heavy metals, on cardiovascular health. Chronic exposure to these pollutants contributes to inflammation, oxidative stress, and endothelial dysfunction, further exacerbating the global burden of CVDs.

Estimated Long-Term Dietary Exposure to Cadmium from Consumption of Spinach in the United States: A Probabilistic Assessment.

As part of the U.S. Food and Drug Administration's (FDA's) Closer to Zero initiative, a toxicological reference value (TRV) for oral dietary exposure to Cd was established.

Impact of chlorine dioxide and chlorhexidine mouthwashes on friction and surface roughness of orthodontic stainless steel wires: an in-vitro comparative study.

Objectives: Good oral hygiene measures are important for successful orthodontic treatment. They involve various types of mouthwashes which have been reported to cause alteration of mechanical properties of archwires. This study aimed to evaluate the effects of a new kind of chlorine-dioxide-containing mouthwash on the mechanical properties and surface morphology of stainless steel orthodontic archwires against the already prevalent chlorhexidine mouthwash in the market.