Local design and manufacturing of patient-specific implant using Anatomage Medical Design Studio software: proof of concept - Botswana's 1st case report.

Background: Botswana, like most sub-Sahara African nations, uses conventional orthopaedic implants that are sourced from major manufactures in the West. The implants are mass-produced and designed with universal configurations to fit an average patient. During surgery, surgeons thus sometimes bend the implants to match the individual bone anatomy, especially for paediatric patients and those with unique deformities, thus risking implant failure.

A country-specific FRAX model for Botswana.

Introduction: Hip fracture rates in Botswana were used to create a FRAX® model for fracture risk assessment.

Objective: This paper describes the development and characteristics of a country-specific FRAX model for Botswana.

Methods: Age-specific and sex-specific incidence of hip fracture and national mortality rates was incorporated into a FRAX model for Botswana.

Epidemiology of hip fracture in Botswana.

Unlabelled: A retrospective population-based survey in the Republic of Botswana determined the incidence of fractures at the hip over 3 years. The estimated number of such fractures nationwide for 2020 was 103 and is predicted to increase.

Objective: This article describes the epidemiology of hip fractures in the Republic of Botswana.

Dual polymer networks: a new strategy in expanding the repertoire of hydrogels for biomedical applications.

Inspired by the double network hydrogel systems we report the formulation of dual networks, which expands the repertoire of this class of materials for potential biomedical applications. The tough dual network hydrogels were designed through sequential interpenetrating polymer formation, applying green chemistry and low-cost methods, devoid of any initiator-activator complexes that may pose risks in biomedical applications. The dual networks were synthesized in two steps, firstly the water soluble poly(vinyl alcohol) was subjected to cryogelation that formed the first network, which was then expanded by intrusion of a dilute solution of sodium alginate and complexed with a solution of calcium chloride under ambient conditions and further freeze-thawed.

Combinatorial design of calcium meta phosphate poly(vinyl alcohol) bone-like biocomposites.

The incidence of degenerative diseases and the ageing population have added to the growing demand for bone grafts. Although autologous bone continues to be the gold standard, limited yield and potential morbidity of the donor site pose considerable challenges. Currently, clinically used synthetic grafts based on calcium phosphates are mechanically brittle and not compliant hence composite scaffolds are expected to be provide viable solutions.