Publications by authors named "S Nityanand"
Role of centchroman in regression of fibroadenoma: A 2-arm randomized control trial.
Clinics (Sao Paulo)
December 2024
Background: Fibroadenomas are common benign breast lumps that can cause anxiety due to malignancy concerns, and Centchroman, a selective estrogen receptor modulator, has shown promise in reducing their size. This study aimed to evaluate the efficacy of Centchroman in reducing fibroadenoma size, mastalgia, anxiety, and depression in affected patients.
Methodology: A parallel-arm randomized controlled trial was conducted at a tertiary care Breast Clinic with 104 patients aged 18‒45 years having fibroadenomas ≤ 3 cm.
Neprilysin (NEP) is a neutral endopeptidase, important for the degradation of amyloid beta (Aβ) peptides and other neuropeptides, including enkephalins, substance P, and bradykinin, in the brain, that influences various physiological processes such as blood pressure homeostasis, pain perception, and neuroinflammation. NEP breaks down Aβ peptides into smaller fragments, preventing the development of detrimental aggregates such as Aβ plaques. NEP clears Aβ plaques predominantly by enzymatic breakdown in the extracellular space.
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- *Researchers identified 34 differentially expressed microRNAs (miRNAs) in EVs from AA patients that target 235 HSPC genes related to important signaling pathways for blood cell formation.
- *The findings suggest that specific miRNAs, particularly miR-139-5p targeting the hub gene IGF-1R, may play a significant role in HSPC function and could be explored as potential treatments for aplastic anemia.
Article Synopsis
- * Methods: The study involved screening for these mutations using various techniques like ARMS PCR, allele-specific PCR, Sanger sequencing, and commercial kits among 378 MPN cases diagnosed in a North Indian tertiary care center over a span of 6.5 years.
- * Results: JAK2V617F mutations were prevalent in most PV, ET
Elevated senescence in the bone marrow mesenchymal stem cells of acquired aplastic anemia patients: A possible implication of DNA damage responses and telomere attrition.
Biochim Biophys Acta Mol Basis Dis
March 2024
Article Synopsis
- Bone marrow mesenchymal stem cells (BM-MSC) play a crucial role in maintaining blood cell production; however, in patients with aplastic anemia (AA), these cells exhibit defects that impact their function.
- The study employed RNA sequencing and various assays to analyze the cellular mechanisms behind these defects in AA BM-MSC, revealing signs of cellular aging (senescence), DNA damage, and reduced telomere length.
- The findings indicate that the compromised functions of AA BM-MSC are linked to their senescent state and associated cellular damages, which negatively affect their ability to support blood cell production in individuals with AA.