Size Attenuated Copper Doped Zirconia Nanoparticles Enhances In Vitro Antimicrobial Properties.

Biofilm formation hinders the activity of antimicrobial drugs at the site of infections and any agent that can act on both Gram-positive and Gram-negative bacteria by inhibiting the bacterial growth and rupturing the biofilm is needed to manage infection. In the present study, we have synthesized zirconia nanoparticles (ZrO NPs) and copper doped zirconia nanoparticles (Cu-ZrO NPs) and characterized them using dynamic light scattering, X-ray diffractometry, and scanning electron microscopy (SEM). The size of the Cu-ZrO NPs drastically reduced compared to ZrO NPs, and the antimicrobial activity was studied against Gram-positive bacteria (Lactobacillus sp.