Publications by authors named "S Nirenjen"
Computational profiling and pharmacokinetic modelling of Febuxostat: Evaluating its potential as a therapeutic agent for diabetic wound healing.
Biochim Biophys Acta Gen Subj
January 2025
Article Synopsis
- Diabetic wounds, common in Type 2 Diabetes, have slow healing due to impaired biological processes; the study investigates Febuxostat as a treatment option.
- Using various methodologies, including computational models and lab assays, researchers assessed Febuxostat's effects on wound healing pathways and its toxicity.
- Results showed Febuxostat has strong binding to key proteins involved in healing, demonstrated efficacy in promoting cell migration and closure in lab tests, and is deemed safe for use, warranting further clinical investigations.
Background: Stevens-Johnson Syndrome (SJS) is an infrequent yet severe mucocutaneous reaction that involves less than 10% of the Body Surface Area (BSA). It is predominantly induced by certain medications, including anticonvulsants (e.g.
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- * In Alzheimer's, genes related to amyloid-beta accumulation are key, while Parkinson's is associated with mutations in the alpha-synuclein gene and other related genes affecting dopamine neurons.
- * Research is focusing on alpha-synuclein as a potential biomarker for both diagnosis and treatment, highlighting its role in disease progression and potential connections between neurodegenerative diseases and other conditions like melanoma.
Article Synopsis
- * A case study of a 41-year-old woman revealed her wrist pain worsened over time, with imaging showing significant bone collapse and complications like secondary osteoarthritis, leading to a diagnosis of Kienbock's disease.
- * The patient underwent a proximal row carpectomy (PRC), which significantly relieved her pain and improved wrist function, highlighting the necessity for precise diagnosis and tailored treatments for this uncommon disease.
Meconium-stained amniotic fluid (MSAF) presents a complex medical scenario with significant implications for maternal and neonatal health. This case report explores the intricacies surrounding MSAF, focusing on its diagnosis, treatment, and the associated meconium aspiration syndrome (MAS). The report emphasizes the critical role of antibiotic prophylaxis in lower segment cesarean sections (LSCS) in balancing infection prevention in the mother with neonatal considerations.
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