Publications by authors named "S Niendorf"

We report an increase in GII.17 norovirus outbreaks and sporadic infections of acute gastroenteritis in Austria, Germany, France, Ireland, the Netherlands, England and the United States during the 2023/24 season. A decrease in GII.

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Article Synopsis
  • Viral gastrointestinal infections are a significant health issue in developing countries, including Burkina Faso, where limited data on the circulating viruses and their genetic diversity exist.
  • This study analyzed stool samples from 1,295 patients between 2018 and 2021, finding that 34.1% had detectable viruses, with norovirus and sapovirus being the most common.
  • The research highlights a reduction in viral prevalence but a high diversity of strains, emphasizing the need for routine surveillance and improved management strategies for diarrhea, particularly for children.
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Background: While the gut microbiome modulates the pathogenesis of enteric viruses, how infections caused by rotavirus A (RVA), with or without diarrhoea, alter the gut microbiota has been sparsely studied.

Methods: From a cohort of 224 vaccine naïve Gabonese children with and without diarrhoea (n = 177 and n = 67, respectively), 48 stool samples were analysed: (i) RVA with diarrhoea (n = 12); (ii) RVA without diarrhoea (n = 12); (iii) diarrhoea without RVA (n = 12); (iv) healthy controls without diarrhoea and RVA (n = 12). The 16S rRNA metabarcoding using Oxford Nanopore sequencing data was analysed for taxonomic composition, abundance, alpha and beta diversity, and metabolic pathways.

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Human norovirus is a major cause of viral gastroenteritis in all age groups. The virus is constantly and rapidly changing, allowing mutations and recombination events to create great diversity of circulating viruses. With the start of the COVID-19 pandemic in 2020, a wide range of public health measures were introduced worldwide to control human-to-human transmission of SARS-CoV-2.

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