Experts' discussion: implications of the World Health Organization's World report on hearing for the cochlear implant field.

Objective: This review aims to analyse the implications of the World Health Organization's 2021 world report on hearing, with a particular focus on the cochlear implant field. The objective is to understand the challenges and opportunities highlighted in the report and propose viable solutions for effective implementation within the cochlear implant community.

Methods: Following the release of the World Health Organization's world report on hearing, cochlear implant professionals explored and discussed the implications of the report with examples from various countries to understand the disparities in access, reimbursement policies, and social stigma associated with hearing loss.

The membrane-associated ubiquitin ligase MARCHF8 promotes cancer immune evasion by degrading MHC class I proteins.

Unlabelled: The loss of major histocompatibility complex class I (MHC-I) molecules has been proposed as a mechanism by which cancer cells evade tumor-specific T cells in immune checkpoint inhibitor (ICI)-refractory patients. Nevertheless, the mechanism by which cancer cells downregulate MHC-I is poorly understood. We report here that membrane-associated RING-CH-type finger 8 (MARCHF8), upregulated by human papillomavirus (HPV), ubiquitinates and degrades MHC-I proteins in HPV-positive head and neck cancer (HPV+ HNC).

Clinical Considerations and Management of a Labially Impacted Maxillary Canine With Immediate Implant Placement and Alveolar Bone Reconstruction: A Case Report.

A labially impacted maxillary canine is a relatively uncommon occurrence. In adult patients, management of impacted maxillary canines becomes necessary when the deciduous canine is lost, or if the impacted tooth becomes symptomatic. Orthodontic realignment is not always the preferred therapeutic approach due to the long treatment duration.

Strategies for crowdsourcing hearing health information: a comparative study of educational programs and volunteer-based campaigns on Wikimedia.

Background: Several health institutions developed strategies to improve health content on Wikimedia platforms given their unparalleled reach. The objective of this study was to compare an online volunteer-based Wikimedia outreach campaign with university course Wikipedia assignments (both focused on improving hearing health content in Wikimedia's public digital knowledge archives), in terms of the reach of the contributions and the extent of the participants' input. A secondary objective was to examine the feasibility and the implementation of the different strategies.