Applications of Surface Plasmon Resonance (SPR) to the Study of Diverse Protein-Ligand Interactions.

Functional characterization of enzymes/proteins requires determination of the binding affinity of small molecules or other biomolecules with the target proteins. Several available techniques, such as proteomics and drug discovery strategies, require a precise and high-throughput assay for rapid and reliable screening of potential candidates for further testing. Surface plasmon resonance (SPR), a well-established label-free technique, directly measures biomolecular affinities.

Driving Errors in Persons with Dementia.

Objectives: To differentiate driving errors in persons with dementia who fail a performance- based road test from errors in persons who pass.

Design: Cross-sectional.

Setting: Community.

Striving for evidence-based practice innovations through a hybrid model journal club: A pilot study.

Objective: The purpose of this study was to pilot a "hybrid" style journal club and determine whether measurable effects could be detected over 8-weeks' time on evidence-based practice ability, desire, behaviors, use, and barriers.

Background: Journal clubs have been suggested as a method to increase nurses' confidence with using research evidence to guide practice. However, it is yet unknown how nurse educators can best implement effective programs for clinicians with varying schedules, education levels, and research skills.

Does attrition during follow-up bias outcome data in studies of eating disorders?

Attrition is a pervasive problem in eating disorders research. This study examined whether those who do and do not respond to follow-up assessments differ before or during treatment. Participants (N=268) receiving residential eating disorders treatment were categorized according to those who did ("responders," n=152) and did not ("non-responders," n=116) complete a one-month follow-up assessment.